邻酰胺基二苯脲类化合物的合成及在农作物上的应用研究

为了寻找高活性新型植物生长调节剂,以靛红酸酐和3-二甲氨基丙胺为起始原料合成中间体2-氨基-N-(3-(二甲基氨基)丙基)苯甲酰胺,再与异氰酸苯酯加成合成目标化合物N-(3-(二甲氨基)丙基)-2-(3-苯基脲基)苯甲酰胺。结构通过元素分析和1H NMR确证,并对小麦、苹果、番茄做了药效试验。结果表明：小麦实验中,目标化合物在低浓度25 μg/mL时,发芽促进率达到了32.6%,高浓度抑制,在12.5 μg/mL时,主根促进率为36.3%,活性优于对照DA-6和清水,田间产量增产17.3%；苹果田间实验中,VC含量增加了35.0%,可溶性糖含量增加了5.87%,单果增产率25.2%,均优于对照化合物二苯脲；番茄田间实验中,在50 μg/mL下,单株坐果数为12,增产率达到了35.3%,优于清水对照。说明目标化合物具有较高的生物活性,为新型植物生长调节剂的合成及活性研究提供了参考。

Synthesis of O-amido Diphenyl Urea and Its Application on Crops

To find new plant growth regulators with high activity, the intermediate 2-amino-N-3-(dimethylamino) propyl] benzamide was synthesized by using isatoic anhydride and DMAPA as the raw material. Phenyl isocyanate was added to the target compound N- 3- (dimethylamino) propyl]- 2- (3- phenylureido) benzamide. The structure was confirmed by elemental analysis and 1H NMR. Then, the efficacy was tested on wheat, apple and tomato. The results showed that in the wheat experiment, when the target compound was at a low concentration of 25 μg/mL, the germination promotion rate reached 32.6% and the high concentration had an inhibition effect. At 12.5 μg/mL, the main root promotion rate reached 36.3%, and the activity was better than that of the control DA- 6 and clear water, the field yield increased by 17.3% ; in the apple field experiment, the VC content increased by 35.0%, the soluble sugar content increased by 5.87%, and the single fruit yield increased by 25.2%, which was better than that of the control compound diphenyl urea; in the tomato field experiment, at 50 μg/mL, the number of fruits per plant was 12 and the increase rate reached 35.3%, which was better than that of the control of clear water. The research indicates that the target compound has high biological activity, and provides references for the synthesis and activity study of new plant growth regulators.