生物技术在鸡球虫免疫研究中的应用

就近几年开发的球虫疫苗和球虫免疫中所涉及的分子细胞生物学、分子免疫学和功能基因组学的相关技术进行了阐述。

Application of Biotechnological Tools in Coceidia Immunology

Coccidiosis is a ubiquitous intestinal protozoan infection for poultry seriously impairing growth and feed utilization of infected animals.The conventional disease control strategy has relied on the prophylactic medication.Due to the continual emergence of drug resistant parasites in the field and the incidence of broiler condemnations,the novel approaches are urgently needed to reduce economic loss.Understanding the basic biology of hostparasite interactions and the protective intestinal immune mechanisms,as well as characterization of host and parasite genes and proteins involved in eliciting protective host responses are crucial for the development of new control strategy.In this review the recent research developments of coccidiosis with special emphasis on the utilization of cutting edge techniques in molecular/cell biology,immunology,and functional genomic in coccidia vaccine were introduced.The information improved the understanding of host-parasite biology,mucosal immunology,and host and parasite genomic in the development of a practical and effective control strategy against Eimeria and the design of nutritional interventions to maximize growth under the stress caused by vaccination or infection.Furthermore,the successful identification of quantitative economic traits associated with disease resistance to coccidiosis was provided for poultry breeders with a novel selection strategy for development of genetically stable,coccidiosis-resistant chickens for the production efficiency.