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| 薯蓣皂苷元微胶囊的制备及体外抗肿瘤活性 | |
| 引用本文： | 李彰鑫,黄文,薛安,李怡,舒丹.薯蓣皂苷元微胶囊的制备及体外抗肿瘤活性[J].安徽农业科学,2010(25):13807-13809. |
| 作者姓名： | 李彰鑫 黄文 薛安 李怡 舒丹 |
| 作者单位： | 1. 北京大学深圳研究生院城市人居环境科学与技术重点实验室,广东深圳,518055;北京大学环境工程系水沙科学教育部重点实验室,北京,100871 2. 四川大学生物治疗国家重点实验室,四川成都,610041 3. 北京大学环境工程系水沙科学教育部重点实验室,北京,100871 |
| 基金项目： | 国家"十一五"科技支撑项目，四川省科技支撑项目 |
| 摘 要： | 目的]制备薯蓣皂苷元微胶囊并对其性能进行表征,探讨微胶囊的体外抗肿瘤活性。方法]通过喷雾干燥技术制备薯蓣皂苷元微胶囊,采用MTT法对它们的体外抗肿瘤活性进行评价。结果]以明胶为壁材制备了薯蓣皂苷元微胶囊,并对微胶囊的粒径分布、超微结构和包封率进行了表征。以明胶薯蓣皂苷元配比为5：1制备的微胶囊,包埋率为78%～94%,平均粒径约13μm。细胞试验表明,当药物浓度为40mg/L时,生物体外培养的人结肠癌细胞（C26）有72%被抑制,具有良好的抑癌效果。薯蓣皂苷元微胶囊对C26细胞体外抗增值活性与薯蓣皂苷元相比有了明显提高。结论]薯蓣皂苷元微胶囊的抗肿瘤活性较薯蓣皂苷元明显提高。 |
| 关 键 词： | 薯蓣皂苷元 喷雾干燥 微胶囊 性能表征 抗肿瘤活性 |
Preparation and in vitro Antitumor Activity of Diosgenin-loaded Microcapsules |
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| LI Zhang-xin et al.Preparation and in vitro Antitumor Activity of Diosgenin-loaded Microcapsules[J].Journal of Anhui Agricultural Sciences,2010(25):13807-13809. | |
| Authors: | LI Zhang-xin |
| Institution: | LI Zhang-xin et al (Key Laboratory for Urban Habitat Environmental Science , Technology,School of Environment , Energy,Peking University Shenzhen Graduate School,Shenzhen,Guangdong 518055) |
| Abstract: | Objective]The paper aims to prepare and characterize diosgenin-loaded microcapsules in order to investigate their in vitro antitumor activity.Method]The diosgenin-loaded microcapsules were prepared by spray drying technique.Their antitumor activity in vitro was evaluated by MTT method.Result]By using gelatin as wall materials,the diosgenin-loaded microcapsules were prepared by spray-drying technique,and the particle size distribution,encapsulation efficiency,ultrastructure and other properties of the mic... |
| Keywords: | Diosgenin Spray drying Microcapsules Characterize Antitumor activity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |