| 石见穿总酚酸对小鼠四氯化碳急性肝损伤的保护作用 |
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| 引用本文： | 陈朋,崔誉蓉,李德芳,郑秋生.石见穿总酚酸对小鼠四氯化碳急性肝损伤的保护作用[J].安徽农业科学,2010,38(9):4607-4609. |
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| 作者姓名： | 陈朋 崔誉蓉 李德芳 郑秋生 |
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| 作者单位： | 1. 烟台大学海洋学院,山东烟台,264005
2. 新疆特种植物药资源教育部重点实验室,新疆石河子,832002 |
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| 基金项目： | 国家十一五支撑计划资助课题(2006BAI06A18);;教育部新世纪优秀人才支持计划资助项目(NCET-06-0918) |
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| 摘 要： | 目的]研究石见穿总酚酸对受四氯化碳损伤的小鼠肝脏保护作用及其可能机制。方法]将60只昆明种小鼠随机分为对照组和模型组,石见穿设高、中、低剂量组,阳性对照组（水飞蓟宾）,共6个组。灌胃给药连续5d,皮下注射1ml/kg50%四氯化碳花生油溶液,24h测定血清天门冬氨基酸转移酶（AST）、丙氨酸氨基转移酶（ALT）及组织中总抗氧化能力（T-AOC）、丙二醛（MDA）、还原型谷胱甘肽（GSH）的含量。结果]与模型组比较,石见穿总酚酸高、中、低剂量组血清AST、ALT活性均显著降低;组织中T-AOC能力、GSH含量显著增加,MDA含量降低,均呈现剂量依赖性变化。病理学切片也显示石见穿总酚酸对肝保护的作用有剂量依赖关系。结论]石见穿总酚酸对小鼠四氯化碳急性肝损伤具有一定的保护作用,作用机制可能与其抗氧化作用有关,石见穿总酚酸可增强组织抗氧化能力,降低四氯化碳引起的脂类过氧化,保护细胞膜免受损伤。
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| 关 键 词： | 急性肝损伤 石见穿总酚酸 总抗氧化力 脂类过氧化 还原性谷胱甘肽 |
Hepatoprotective Effects of Phenolic Acid from Salvia chinensis Benth. on Carbon Tetrachloride-Induced Acute Liver Injury in Mice |
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| CHEN Peng et al.Hepatoprotective Effects of Phenolic Acid from Salvia chinensis Benth. on Carbon Tetrachloride-Induced Acute Liver Injury in Mice[J].Journal of Anhui Agricultural Sciences,2010,38(9):4607-4609. |
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| Authors: | CHEN Peng |
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| Institution: | Ocean School of Yantai University;Yantai;Shandong 264005 |
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| Abstract: | Objective] To study the protective effect of phenolic acid from Salvia chinensis Benth. (PAS) against CCl4-induced acute liver injury in mice and its possible mechanism. Method] Mice were divided into control group,model group randomly,Salvia chinensis Benth. was divided into 6 groups such as high,medium and low-dose treatment group and positive group (Silibinin). Mice were pretreated by phenolic acid (i.g) for 5 days. Hepatic injury was induced by injecting 1 ml/kg 50% peanut oil solution of carbon tetra... |
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| Keywords: | Acute liver injury Total phenolic acids of Salvia chinensis Benth Total antioxidative capacity Lipid peroxidation Glutathione |
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