复方霍山石斛浸膏增强免疫力作用的研究 |
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引用本文: | 张炜玲,李滨,王新生,李耀亭,谢亚凤.复方霍山石斛浸膏增强免疫力作用的研究[J].安徽农业科学,2012(30):14792-14794. |
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作者姓名: | 张炜玲 李滨 王新生 李耀亭 谢亚凤 |
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作者单位: | 安徽圣农生物科技股份有限公司;安徽省植物细胞工程技术研究中心 |
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基金项目: | 国家科学技术部农业科技成果转化重点项目(SQ2011ECC300092) |
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摘 要: | 目的]研究复方霍山石斛浸膏对小鼠免疫力的影响。方法]将200只健康雌性小鼠分为5个试验组,每组分高、中、低和空白对照4个剂量组3.0、1.0、0.5、0 g/(kg.bw)],连续灌胃给药30 d后分别对不同剂量组小鼠进行细胞免疫的功能检测(ConA诱导小鼠脾淋巴细胞转化试验、DNFB诱导小鼠DTH试验)、体液免疫功能检测(抗体生成细胞检测试验、血清溶血素测定试验)、单核-巨噬细胞功能检测(小鼠炭粒廓清试验、小鼠腹腔巨噬细胞吞噬鸡红细胞试验)和NK细胞活性测定。结果]各项检测结果与空白对照组相比,均能刺激小鼠脾淋巴细胞增殖、转化作用,促进小鼠迟发型变态反应作用,提高小鼠抗体生成细胞数和血清溶血素水平,增强小鼠的单核-腹腔巨噬细胞吞噬、碳廓清能力及NK细胞的活性。结论]复方霍山石斛浸膏具有增强免疫力功能。
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关 键 词: | 霍山石斛 浸膏 小鼠 免疫力 |
Research on Enhancing Immunity of the Extracts of Dendrobium huoshanense |
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Institution: | ZHANG Wei-ling et al(Anhui Sannor Biotechnology Co.,Ltd.,Lu’an,Anhui 237012) |
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Abstract: | Objective] To study the effect of the extract of Dendrobium huoshanense on the immune function of mice.Method] The mice were fed with the extract at the dose of 3.0,1.0,0.5 and 0 respectively,once a day for 30 days,and then 7 indexes of immune function were measured to judge the effect of the extract on immune system.Result] In comparison with the control group,all the results of the experimental groups showed the enhancement on transformation and proliferation of splenic lymphocyte;the quantity of the mice antibody-producing cell and the sheep erythrocyte antibody levels in serum were also raised.The mononuclear macrophage ability to eliminate carbon and mononuclear celiac macrophage phagocytic activity were increased;the delayed hypersensitivity was accelerated,and the activity of NK cell was improved obviously.Conclusion] The extract could enhance immune function of mice. |
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Keywords: | Dendrobium huoshanense Extract Mice Immunity |
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