| 牛蒡子醇提物抑制小鼠宫颈癌U14生长的研究 |
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| 引用本文： | 耿果霞,龙玲,李青旺,王建华.牛蒡子醇提物抑制小鼠宫颈癌U14生长的研究[J].安徽农业科学,2006,34(21):5559-5560. |
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| 作者姓名： | 耿果霞 龙玲 李青旺 王建华 |
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| 作者单位： | 西北农林科技大学动物科技学院,陕西杨凌,712100;西北农林科技大学动物科技学院,陕西杨凌,712100;西北农林科技大学动物科技学院,陕西杨凌,712100;西北农林科技大学动物科技学院,陕西杨凌,712100 |
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| 摘 要： | 通过建立小鼠宫颈癌U14实体瘤与腹水瘤2种动物模型,观察牛蒡子醇提物对实体瘤抑瘤率和腹水瘤生命延长率的影响。结果发现,以阴性对照组为基础,牛蒡子醇提物3个剂量组及环磷酰胺(CTX)阳性对照组实体瘤各组抑瘤率分别为31.7%、49.7%、57.4%和83.6%(P<0.01);腹水瘤各组生命延长率分别为39.8%、46.6%、62.5%和91.6%(P<0.01)。表明牛蒡子醇提物对小鼠宫颈癌U14的生长有一定的抑制作用。
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| 关 键 词： | 牛蒡子 U14 实体瘤 腹水瘤 |
| 文章编号： | 0517-6611（2006）21-5559-02 |
| 收稿时间： | 08 5 2006 12:00AM |
| 修稿时间： | 2006-08-05 |
Study on Effect of the Extract from Fructus arctii on the Uterine Cervical Carcinoma(U_(14)) Growth of Mice Harboring Tumor |
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| GENG Guo-xia ,et al.Study on Effect of the Extract from Fructus arctii on the Uterine Cervical Carcinoma(U_(14)) Growth of Mice Harboring Tumor[J].Journal of Anhui Agricultural Sciences,2006,34(21):5559-5560. |
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| Authors: | GENG Guo-xia |
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| Institution: | College of Animal Science, Northwest Agriculture and Forestry University,Yangling, Shaanxi 712100 |
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| Abstract: | The investigation of the effect of Fructus arctii extract on anti-tumor of mice bearing uterine cervical carcinoma(U_(14))was studied.The effect of Fructus arctii extract on the inhibition rate of solid tumor and the life span of ascites tumor were conducted with the experiment model in vivo of animal tumor.Compared with the control group,the Fructus arctii extract(1?000,2?000 and 4?000 mg/kg body weight) and CTX(25 mg/kg body weight) significantly reduced the tumor weight of solid tumor and increased the life span of ascites tumor harboring mice(P<0.01).The inhibition rate of solid tumor and the rate of life span were up to 31.7, 49.7,57.4 and 83.6%,and 39.8,46.6,62.5 and 91.6%,respectively.The result indicated that Fructus arctii extract had antitumor action. |
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| Keywords: | Fructus arctii Uterine cervical carcinoma(U_(14)) Solid tumor Ascites tumor |
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