| 奶牛OLR1 3′UTR A223C多态的生物学信息分析 |
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| 引用本文： | 张传生,耿立英,尹春光,曹顶国,刘铮铸,付志新.奶牛OLR1 3′UTR A223C多态的生物学信息分析[J].安徽农业科学,2011,39(1):75-77. |
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| 作者姓名： | 张传生 耿立英 尹春光 曹顶国 刘铮铸 付志新 |
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| 作者单位： | 河北科技师范学院,河北昌黎,066600;济宁学院,山东济宁,273155;山东省农业科学院家禽研究所,山东济南,250023 |
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| 基金项目： | 国家科技支撑计划项目(2008BADB2B04-8-4); 河北省自然科学基金项目(C2008001308); 河北省高等学校自然科学研究项目(2010129) |
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| 摘 要： | 目的]探索氧化型低密度脂蛋白受体OLR1 3＇UTR A223C多态与奶牛乳脂率高低紧密关联的分子机制。方法]用miRanda（1.0）软件装载牛microRNA数据库,预测OLR1 3＇UTR潜在的microRNA。结果]共预测16个microRNA靶标,OLR1 3＇UTR A223C突变定位于bta-miR-370靶标种子序列的互补区。结论]由于OLR1 3＇UTR A→C突变导致bta-miR-370靶标的消失,为OLR1 3＇UTR A223C多态与奶牛乳脂率高低紧密关联的分子机制深入研究提供依据。
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| 关 键 词： | OLR1 3′UTR mir-370 生物信息 microRNA |
Bioinformatics Analysis of A223C Polymorphism at the 3′UTR of OLR1 Gene in Cow |
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| ZHANG Chuan-sheng et al.Bioinformatics Analysis of A223C Polymorphism at the 3′UTR of OLR1 Gene in Cow[J].Journal of Anhui Agricultural Sciences,2011,39(1):75-77. |
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| Authors: | ZHANG Chuan-sheng |
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| Institution: | ZHANG Chuan-sheng et al (Hebei Normal University of Science & Technology,Changli,Hebei 066600) |
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| Abstract: | Objective]The aim was to explore the molecular mechanisms of the A223C polymorphism at 3′UTR of oxidized low density lipoprotein receptor(OLR1) which was closely related to milk fat percentage in cow. Method]The putative microRNA targets located in the 3′UTR of OLR1were predicted with the soft miRanda(1.0) which could carry the microRNA dateabase of cow.Result]Total 16 microRNA targets were found. The A223C SNP was located in complementary region of bta-miR-370 target sequence.Conclusion]OLR1 3′UTR A→C mutation had lead to the disappearing of bta-miR-370 target,which had provide basis for the further research on the molecular mechanisms of the A223C polymorphism at 3′UTR of OLR1 gene which was closely related to milk fat percentage in cow. |
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| Keywords: | OLR1 mir-370 microRNA |
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