| 基于c-Met激酶的小分子抑制剂研究进展 |
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| 引用本文： | 李丽丽,艾晓杰.基于c-Met激酶的小分子抑制剂研究进展[J].安徽农业科学,2016,44(13):153-156. |
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| 作者姓名： | 李丽丽 艾晓杰 |
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| 作者单位： | 上海交通大学农业与生物学院，上海市兽医生物技术重点实验室，上海200240;上海美迪西生物医药股份有限公司，上海201299;上海交通大学农业与生物学院，上海市兽医生物技术重点实验室，上海200240 |
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| 摘 要： | HGF/c-Met信号通路在肿瘤的发生、发展和转移中起着重要的调节作用，成为抗肿瘤药物研发的热门靶点。介绍了c-Met 信号通路的作用机制以及c-Met 抑制剂的研究进展，以期能够找到一类肿瘤抑制活性高、选择性好、副作用小的抑制剂，为癌症治疗提供新的途径。
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| 关 键 词： | 受体酪氨酸激酶 c-Met 小分子抑制剂 抗肿瘤 |
Research Progress of Small Molecule Inhibitor Based on c-Met Kinase |
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| LI Lili,AI Xiao-jie.Research Progress of Small Molecule Inhibitor Based on c-Met Kinase[J].Journal of Anhui Agricultural Sciences,2016,44(13):153-156. |
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| Authors: | LI Lili AI Xiao-jie |
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| Abstract: | The HGF/c-Met signaling pathway plays important regulating roles in tumorigenesis, tumor development and transfer, which has be-come the popular target for the research on antitumor drug. We reviewed the research progress of the action mechanism of c-Met signaling pathway and the c-Met inhibitor, aiming at finding an inhibitor with high activity, good selectivity and small side effect, and offering new approach for cancer therapy. |
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| Keywords: | Receptor tyrosine kinases (RTKs) c-Met Small molecule inhibitor Anti-tumor |
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