罗布麻叶水煎剂抗炎作用的研究

目的]研究罗布麻叶水煎剂对小鼠的抗炎作用。方法]将小鼠分为4组:模型对照组,罗布麻叶水煎剂高、低剂量组(6、3 g/kg)和药物对照组(醋酸地塞米松);采用二甲苯致耳廓肿胀、醋酸致腹腔毛细血管通透性增加、角叉菜胶致足肿胀模型研究罗布麻叶水煎剂的抗炎作用。结果]灌胃高、低剂量的罗布麻叶水煎剂对二甲苯所致小鼠耳廓肿胀、角叉菜胶所致小鼠足肿胀均有明显抑制作用,并且可降低小鼠炎症组织中PGE2的含量;高剂量罗布麻叶水煎剂可明显抑制醋酸致小鼠腹腔毛细血管通透性的增加。结论]罗布麻叶对急性炎症具有明显的抗炎效果。

Study on Anti-inflammatory Effect of the Water Extract of Apocynum venetum Leaves

Objective] To study the anti-inflammatory effects of the water extract of Apocynum venetum leaves.Method] Mice were divided into four groups,model control group,high,low dosage（6,3 g/kg） group of the water extract of Apocynum venetum leaves,medicine control group（Dexamethasone acetate）.Three types of models of acute inflammatory were used to observe the anti-inflammatory effect of the water extract of Apocynum venetum leaves.Result] The experimental results suggested that the water extraction of Apocynum venetum leaves（6,3 g/kg） has obvious inhibition for the swelling of auricle in mice caused by dimethyl benzene,the paw edema induced by carrageenan,and the synthesis of PGE2 in the injected paw of mice caused by carrageenan.The high dosage extraction of Apocynum venetum leaves（6 g/kg） has also inhibited significantly the increase in vascular permeability caused by acetic acid.Conclusion] Apocynum venetum leaves have good antiinflammatory effects on acute inflammation.