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正常孕妇与妊高症患者胎盘中Ghrelin、GHS-R mRNA的表达研究
引用本文:姜丽萍,刘德斌,杜晨光,李海军,赵鹏伟,钱英红,杨燕燕,曹贵方.正常孕妇与妊高症患者胎盘中Ghrelin、GHS-R mRNA的表达研究[J].安徽农业科学,2009,37(12):5367-5369.
作者姓名:姜丽萍  刘德斌  杜晨光  李海军  赵鹏伟  钱英红  杨燕燕  曹贵方
作者单位:内蒙古农业大学动物科学与医学学院,内蒙古呼和浩特,010018;内蒙古医学院组织胚胎学教研室,内蒙古呼和浩特,010059;内蒙古自治区医院,内蒙古呼和浩特,010035;内蒙古自治区人民检察院技术处,内蒙古呼和浩特,010011;内蒙古农业大学动物科学与医学学院,内蒙古呼和浩特,010018
基金项目:国家自然科学基金项目(30860201)
摘    要:目的]通过比较正常孕妇与妊高症患者胎盘中Ghrelin及其受体GHS-RmRNA水平的变化,探讨Ghrelin及其受体与妊高症的发病是否相关。方法]采用实时荧光定量RT-PCR技术检测了正常孕妇胎盘和妊高症患者胎盘中Ghrelin及其受体GHS-RmRNA水平相对表达量的变化。结果]正常孕妇胎盘组织中mRNA水平与妊高症患者胎盘组织中mRNA水平无显著性差异,但Ghrelin受体GHS-R在两者之间的mRNA水平有显著性差异(P〈0.05)。结论]Ghrelin及其受体在妊高症患者和正常孕妇胎盘中表达的相对变化表明,Ghrelin受体缺乏可能成为妊高症发病的因素之一。

关 键 词:妊高症  胎盘  生长素  实时定量RT-PCR

Expression Research of Ghrelin and its Receptor(GHS-R) mRNA in the Placenta of Normal Pregnant Women and Pregnancy-induce Hypertension Syndrome Patients
JIANG Li-ping et al.Expression Research of Ghrelin and its Receptor(GHS-R) mRNA in the Placenta of Normal Pregnant Women and Pregnancy-induce Hypertension Syndrome Patients[J].Journal of Anhui Agricultural Sciences,2009,37(12):5367-5369.
Authors:JIANG Li-ping
Institution:JIANG Li-ping et al(College of Animal Science , Animal Medicine,Inner Mongolia Agricultural University,Hohhot,Inner Mongolia 010018)
Abstract:Objective] The aim was to discussed the correlations of Ghrelin and its receptor(GHS-R) and pregnancy-induced hypertension syndrome by comparing with normal pregnant women and pregnancy-induced hypertension syndrome patients in Ghrelin and its receptor(GHS-R) mRNA level changes.Method] Ghrelin and its receptor(GHS-R) mRNA expression changes were detected in normal pregnancy women and pregnancy-induced hypertension syndrome patients by using real-time quantitative RT-PCR.Result] The mRNA level was no sign...
Keywords:Pregnancy-induced hypertension syndrome  Placenta  Ghrelin  Real-time quantitative RT-PCR  
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