| 低剂量四环素诱导嗜水气单胞菌产生耐药性的分析 |
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| 引用本文： | 蔡丽娟,朱丽敏,刘凯,许宝青,林启存.低剂量四环素诱导嗜水气单胞菌产生耐药性的分析[J].安徽农业科学,2013(17):7564-7564,7567. |
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| 作者姓名： | 蔡丽娟 朱丽敏 刘凯 许宝青 林启存 |
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| 作者单位： | 杭州农业科学研究院,浙江杭州,310024;杭州农业科学研究院,浙江杭州,310024;杭州农业科学研究院,浙江杭州,310024;杭州农业科学研究院,浙江杭州,310024;杭州农业科学研究院,浙江杭州,310024 |
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| 基金项目： | 杭州市农业科研项目，浙江省重点科技创新团队计划资助项目 |
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| 摘 要： | 目的]探索抗生素长期低剂量浓度刺激对致病菌耐药性产生的影响。方法]以盐酸四环素为例,对1株鳖源嗜水气单胞菌开展抗生素耐药诱导试验。用盐酸四环素亚抑菌浓度(1/2MIC)持续4代(每代诱导72 h)刺激1株鳖源嗜水气单胞菌。结果]这株嗜水气单胞菌对四环素由敏感转至耐药。结论]四环素亚抑菌浓度长期刺激对致病菌有较强的致耐药作用。该研究对养殖用药具有一定的指导意义。
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| 关 键 词： | 四环素 耐药诱导 亚抑菌浓度 嗜水气单胞菌 |
Analysis on Resistance Induction of Aeromonas hydrophila by Low Dose Tetracycline's Continuous Stimulation |
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| Institution: | CAI Li-juan;Hangzhou Academy of Agricultural Sciences; |
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| Abstract: | Objective j To investigate resistance induction of pathogenic bacteria treated with low dose antibiotics＇ continuous stimulation. Method] An Aeiomonas hydrophila strain isolated from soft-shelled turtle was cultivated after 4 sequential subcultures in sub-inhibitory concen- trations of Tetracycline. Result] Aeror, wnas hydrophila was induced drug tolerance. Conclusion] Low dose Tetracycline＇s continuous stimula- tion could produce resistance induction of pathogenic bacteria, the study has a guiding significance for the use of antibiotic drugs in aquaculture. |
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| Keywords: | Tetracycline Resistance induction Sub-inhibitory concentrations Aeromonas hydrophila |
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