四川省不同地区猪源大肠杆菌耐药性调查

目的]了解四川省不同地区猪源大肠杆菌的耐药性。方法]采用CLSI推荐的微量肉汤稀释法,对分离自四川各地不同养猪场的232株大肠杆菌对32种抗菌药物的耐药性进行调查。结果]232株大肠杆菌除对头孢噻呋、头孢唑啉、头孢曲松和阿米卡星较敏感（耐药率≤15.52%）外,对其余28种药物均表现出不同程度的耐药性（耐药率范围42%～97%）;98.7%的菌株表现出多重耐药性;对部分药物,分离自规模化养殖场菌株的耐药性比分离自散养户的菌株严重。结论]分离菌株对大部分抗菌药物均表现出耐药性。

Surveillance of Antibiotic Resistance among Escherichia coli Isolated from Swine in Different Areas of Sichuan Province

Objective] To get messages of antibiotic resistance in swine E.coli isolates from different areas in Sichuan province.Method] Antibiotic resistance of 232 E.coli isolates from different pig farms in Sichuan province to 32 antimicrobial agents was surveyed.Broth microdilution method according to the recommendation of the CLSI was used.Result] Lower antibiotic resistance rate(≤15.52%) against ceftiofur,cefazolin,amikacin,and higher antibiotic resistance rate(42%-97%) against the other 28 agents were observed in 232 E.coli isolates,respectively.98.7% of all isolates possessed multi-drug resistance.To some antibiotics,the antibiotic resistance of E.coli isolates from large scale farms was more serious than isolates from individual farms.Conclusion] Antibiotic resistance among the E.coli isolates to most of the antimicrobial agents is existed.