丹酚酸B重要中间体的合成与表征

［目的］探讨二氢苯并呋喃衍生物的人工合成及其影响因素。［方法］以异香兰醛为原料，经过6步反应最终合成二氢苯并呋喃衍生物。［结果］在第1步反应中产物2溴3羟基4甲氧基苯甲醛的收率为93.2%。在第2步反应中产物2溴3甲酰基6甲氧基苯乙酯的收率为96.3%。在第3步反应中产物缩醛的收率为97.7%。在第4步反应中，以溴代苯和丙二酸二乙酯为原料，乙醇钠作强碱，CuBr作催化剂，六甲基磷酰三胺（HMPA）作溶剂，在氮气的保护下加热回流12h，产物取代苯丙二酸二乙酯的收率为39.1%。在第5步反应中产物1羟基2甲氧基6甲酰基苯乙酸的收率为95.6%。在第6步反应中产物二氢苯并呋喃衍生物为淡黄色固体，收率为65.2%，熔点为159-162℃。［结论］该研究为丹酚酸B及其类似物的合成奠定了理论基础。

Synthesis and Characterization of the Important Intermediate of Salvianolic Acid B

Objective] The purpose of the research was to discuss the artificial synthesis of dihydrobenzofuran derivative and its influencing factors.Method] With 3-hydroxy-4-methoxybenzaldehyde as raw material,the dihydrobenzofuran derivative was synthesized through 6-step process finally.Result] In the first-step reaction,the yield rate of the product 2-bromo-3-hydroxy-4-methoxybenzaldehyde was 93.2%.In the second-step reaction,the yield rate of the product 2-bromo-3-formyl-6-methoxyphenethyl ester was 96.3%.In t...