过山青水提物对小鼠肝·肾功能及血细胞计数的急性毒性研究

目的]通过过山青对小鼠的急性毒性试验,确定过山青水提取物短期内使用有无毒性。方法]将不同浓度的过山青灌喂小鼠后,连续观察10 d,记录小鼠体征及活动情况,并检测小鼠的肝肾功能和血常规。结果]过山青水提物对小鼠的血常规中白细胞的影响大,但没有线性关系,高低计量影响相对较小,而中剂量的影响却很大。过山青水提物对淋巴细胞和单核细胞的影响不大,对中性粒细胞的影响比较大,对红细胞的影响,除D组外,影响较小,对血红蛋白的影响也不明显。过山青对小鼠体征及活动情况无明显影响,使血液中白细胞和中性粒细胞降低,导致免疫功能下降;较大剂量时导致肝脏毒性,对肾脏的影响不明显。结论]过山青水提取物对小鼠有一定的毒理作用,较大剂量时毒性较大。

Acute Toxicity of Reinwardtia trigyna Water Extracts to Mice Liver, Renal Function and Blood Cell Count

Objective] To detect the toxicity of R.trigyna water extracts in short term based on the acute toxicity test to mice.Method] Effects of R.trigyna water extracts on the mice leukocyte were the greatest,but the two showed no linear relationship.The low and high dosages had little effects but the middle dosage had significant effects.R.trigyna water extracts had few effects on lymphocyt and monocyte,had great effects on neutrophil,had relatively small effects on erythrocyte except group D,and had no significant effects on hemoglobin.R.trigyna had no significant effects on the physical signs and activity condition of mice,which reduced the leukocyte and neutrophil in blood and led to the decrease of immune function.High dosage caused the liver toxicity and had no significant effects on kidney.Conclusion] R.trigyna water extracts had certain toxicological effects on mice,and high dosage had great toxicity.