ICL、ICDH、ODH和GDH酶与L-谷氨酸的合成 |
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引用本文: | 余秉琦,朱劼,何玉财,蔡志强,王利群,杨林松.ICL、ICDH、ODH和GDH酶与L-谷氨酸的合成[J].安徽农业科学,2010,38(30):16725-16727,16730. |
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作者姓名: | 余秉琦 朱劼 何玉财 蔡志强 王利群 杨林松 |
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作者单位: | 常州大学化学化工学院,江苏常州,213164;常州大学化学化工学院,江苏常州,213164;常州大学化学化工学院,江苏常州,213164;常州大学化学化工学院,江苏常州,213164;常州大学化学化工学院,江苏常州,213164;常州大学化学化工学院,江苏常州,213164 |
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摘 要: | 通过对对数生长期细胞的异柠檬酸裂解酶(ICL)、异柠檬酸脱氢酶(ICDH)、α-酮戊二酸脱氢酶(ODH)和谷氨酸脱氢酶(GDH)的分析以及对细胞L-谷氨酸产生量和发酵残糖的综合分析,发现由于乙醛酸循环关键酶ICL的缺失,L-谷氨酸产生量大幅下降,说明乙醛酸循环是谷氨酸棒杆菌中的主要回补途径,L-谷氨酸合成需要乙醛酸循环。在保证乙醛酸循环回补功能的前提下,提高ICDH活性,减弱ODH活性,有利于L-谷氨酸的合成。
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关 键 词: | 谷氨酸 异柠檬酸裂解酶 异柠檬酸脱氢酶 α-酮戊二酸脱氢酶 谷氨酸脱氢酶 |
Effect of ICL, ICDH, ODH and GDH on L-Glutamate Production |
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Institution: | YU Bing-qi et al (Chemistry and Chemical Engineering Institute,Changzhou University,Changzhou,Jiangsu 213164) |
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Abstract: | Investigation into relationship between L-glutamate production and enzymes isocitrate lyase(ICL),isocitrate dehydrogenase(ICDH),2-oxoglutarate dehydrogenase(ODH)as well as glutamate dehydrogenase(GDH) from cells in the logarithmic growth phase was carried out.The results indicated that the glyoxylic cycle was the main anaplerotic pathway and indispensable for L-glutamate production in C.glutamicum.Furthermore,it was revealed that L-glutamate production could be stimulated when ICDH activity increased and ODH activity decreased in existence of the glyoxylic anaplerotic pathway. |
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Keywords: | L-glutamate Isocitrate lyase(ICL) Isocitrate Dehydrogenase(ICDH) 2-oxoglutarate dehydrogenase(ODH) Glutamate dehydrogenase(GDH) |
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