粗茎秦艽中的人工生物碱及化学成分研究

目的]研究粗茎秦艽中的人工生物碱及其他化学成分。方法]以含氨溶剂对粗茎秦艽进行提取后,利用硅胶色谱分离纯化该浸膏中的化学成分,根据化合物的理化性质和光谱数据鉴定化合物的结构。结果]分离并鉴定了8个化合物,其结构分别为粗茎龙胆碱A(gentiocrasine A,Ⅰ)、粗茎龙胆碱B(gentiocrasine B,Ⅱ)、秦艽甲素(gentianine,Ⅲ)、秦艽丙素(gentianal,Ⅳ)、西藏龙胆碱(gentiatibetine,Ⅴ)、胡萝卜苷(daucosterol,Ⅵ)、β-谷甾醇(β-sitosterol,Ⅶ)、棕榈酸(plamitic acid,Ⅷ)。结论]化合物Ⅰ和化合物Ⅱ为首次得到的化合物。

Artificial Alkaloids and Chemical Constituents of Gentiana crassicaulis Duthie ex Burk

Objective] To study artificial alkaloids and other chemical constituents of Gentiana crassicaulis Duthie ex Burk..Method] After the crude total alkaloids were extracted with a solvent containing ammonia ,the chemical constituents in the extract were isolated and purified by silica gel column chromatography and identified on the basis of their physiochemical and spectral data .Result] Eight compounds were isolated and identified,including gentiocrasine A (Ⅰ),gentiocrasine B (Ⅱ),gentianine (Ⅲ),gentianal (Ⅳ),gentiatibetine (Ⅴ),daucosterol (Ⅵ),β-si-tosterol (Ⅶ),and plamitic acid (Ⅷ).Conclusion] CompoundsⅠandⅡare new compounds.