2味中药复方对大鼠胃黏膜损伤保护作用及血液指标的影响

目的]观察2味中药复方(LWZY)抗大鼠胃黏膜损伤作用及对血液指标的影响。方法]采用无水乙醇致大鼠胃黏膜损伤模型、阿司匹林致大鼠胃黏膜损伤模型、盐酸致大鼠胃黏膜损伤模型,预防性灌胃给药,以胃黏膜的损伤指数、凝血酶原时间(PT)、纤维蛋白原(FIB)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)为指标,评价2味中药复方药剂对各动物模型的抗胃黏膜损伤作用及对血液指标的影响。结果]西米替丁及LWZY各给药组对阿司匹林大鼠胃黏膜损伤模型、盐酸大鼠胃黏膜损伤模型、无水乙醇大鼠胃黏膜损伤模型均有明显的保护作用,各给药组胃黏膜损伤指数均较模型组明显降低(P0.05;P0.01);无水乙醇模型中的血液值;LWZY组较模型组比较PT、FIB、APTT、TT值有明显降低(P0.05;P0.01),有统计学意义;盐酸模型中的血液值,模型组PT、FIB、APTT、TT值较正常组比较略有升高,LWZY组较模型组比较PT、FIB值有明显降低,但无统计学意义,而APTT、TT值有明显降低(P0.05;P0.01),有统计学意义;阿司匹林模型中的血液指标中模型组PT、FIB、APTT、TT值较正常组比较明显升高,LWZY组较模型组比较PT、FIB、APTT、TT值有明显降低(P0.05;P0.01),有统计学意义。结论]LWZY对无水乙醇、阿司匹林、盐酸致大鼠胃黏膜损伤有明显的保护作用,并且有一定的体内促凝血作用,作用机制可能和凝血因子以及调节激素水平有关。

Effect of Two Chinese Herbal Compounds on the Protection of Gastric Mucosal Lesion in Rat and Its Blood Index

Objective] To observe the effects of two Chinese herbal compounds(LWZY) on the protection of gastric mucosal lesion in rat and its blood index.Method] By using the model of gastric mucosal lesion by anhydrous alcohol,the model of gastric mucosal lesion by aspirin,the model of gastric mucosal lesion by hydrochloric acid,the preventive medicine was intragastrically administrated,the indices of gastric mucosa damage index,prothrombin time(PT),fibrinogen(FIB),activate part blood coagulation time(APTT) and thrombin time(TT) were selected to evaluate the anti-gastric mucosal lesion performance of two Chinese herbal compounds and its impact on the blood index.Result] Cimetidine and LWZY each dose treatment group had significant protective effects on rats in model of gastric mucosal lesion by anhydrous alcohol,the model of gastric mucosal lesion by aspirin and the model of gastric mucosal lesion by hydrochloric acid,the gastric mucosa damage index of all treatment groups significantly reduced compared with that of model group(P< 0.05;P<0.01),the blood in the anhydrous alcohol model with LWZY reduced significantly in PT,FIB,APTT and TT compared to the normal group(P<0.05;P<0.01) with a statistic significance;the blood in the hydrochloric acid model increased slightly in PT,FIB,APTT and TT than the normal group;PT,and FIB of LWZY group significantly reduced compared with model group,but without statistic significance,APTT and TT were reduced significantly(P<0.05;P<0.01),and had a statistic significance,the index of blood in aspirin model PT,FIB,APTT and TT are marked increase with the normal group,model group with LWZY is reduced significantly in PT,FIB,APTT and TT compared to model group(P<0.05;P<0.01),and had statistic significance.Conclusion] LWZY could significantly protect the anhydrous alcohol,aspirin,hydrochloric acid caused rat gastric mucosa damage,and promote blood clotting in vivo,the action mechanism might be related to the blood coagulation factor and hormone level.