野生蒲公英联合高山红景天对糖尿病模型小鼠的降血糖作用研究

目的]探讨长白山野生蒲公英（Taraxacum mongolicum）联合高山红景天（Rhodiola sachalinensis）对糖尿病小鼠的降血糖影响。方法]选取30只昆明种小鼠,其中24只造成糖尿病模型,分为5组,分别为正常对照组、四氧嘧啶模型组、高山红景天组、长白山野生蒲公英组和联合剂量组。采用自制的水煎液进行灌胃给药,1次/d,连续5 d,测定糖尿病模型小鼠的血糖值。结果]给药5 d后,各试验组小鼠血糖浓度均明显降低,与四氧嘧啶模型组相比存在极显著差异（P〈0.01）。结论]高山红景天、长白山野生蒲公英、高山红景天与蒲公英联合对糖尿病小鼠都有明显的降血糖作用。

Study on Combined Hypoglycemic Effect of Wild Taraxacum mongolicum and Rhodiola sachalinensis on Diabetic Mice

Objective] The aim was to study the combined hypoglycemic effect of wild Taraxacum mongolicum and Rhodiola sachalinensis in Changbai Mountain on diabetic mice.Method] Thirty kunming mice were selected,among which 24 became diabetes model by man-made methods.Thirty mice were divided into five groups,including blank control group,alloxan group,Rhodiola sachalinensis group,wild Taraxacum mongolicum group and combined dose group.The mice in Rhodiola sachalinensis group,wild Taraxacum mongolicum group and combined dose group received intragastric administration of self-made water decoction for five days continuously,one time per day,and then their blood glucose were detected.Result] The blood glucose of diabetic mice in each group all lowered five days after the intragastric administration,which had an extremely significant difference from the alloxan group(P<0.01).Conclusion] Rhodiola sachalinensis,wild Taraxacum mongolicum as well as the combined treatment of Rhodiola sachalinensis and wild Taraxacum mongolicum all had significant hypoglycemic effect on diabetic mice.