基于bipppx(吡唑类)金属配合物的合成及抑菌性能研究

目的]以双3-（4-吡啶）吡唑基]-对二甲苯（bipppx）为配体与锌（Ⅱ）、镉（Ⅱ）、铜（Ⅱ）、钴（Ⅱ）的4种金属盐进行反应合成4种配合物,并对其进行抑菌活性研究。方法]将配体bipppx溶于无水乙醇中,分别加入硝酸锌、乙酸镉、乙酸铜、乙酸钴,加热回流,过滤干燥得目标化合物;运用紫外光谱分析其配位情况;采用纸片法对其进行抑菌活性研究。结果]抑菌活性试验结果表明,配体及配合物对大肠杆菌、产气杆菌的抑菌性较为明显,对金黄色葡萄球菌无明显抑菌作用,并且以bipppx-Co（Ⅱ）配合物的抑菌活性最佳。结论]bipp-px金属配合物的制备为配位化学增添新的内容,良好的抑菌活性为其在农业、医药上的应用提供了依据。

Synthesis and Antibacterial Performance Research of Bipppx Metal-based Complexes

Objective] Let the ligand,the bis 3-(4-pyridyl) pyrazolyl]-p-xylene(bipppx)react with four salts,the Zinc nitrate,Cadmium acetate,Copper acetate and Cobalt acetate to get four complexes.Then we research the bacteriostatic activity of them.Method] Let the ligand dissolve in absolute ethyl alcohol,mix with four kinds of Zn(Ⅱ),Cd(Ⅱ),Co(Ⅱ),Cu(Ⅱ) metal salts separately.After heat under reflux,filtration and drying,we get the target compounds.Apply the UV-spectrometry to analyze the coordination.Use the paper strip to exam the complexes' bacteriostatic activity.Result] The result of bacteriostatic activity experiments shows that the complexes have bacteriostatic action on the Escherichia coli and E.aerogenes,but have little effects on the Staphylococcus aureus.Moreover,the bipppx-Co(Ⅱ)'s bacteriostatic activity is very obviously.Conclusion] The preparation of the bipppx metal complexes provides new content for the coordination chemistry.Good bacteriostatic activity provides the basis for its application in agriculture and medicine.