灵芝草提取物的体内抗氧化活性研究 |
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引用本文: | 刘广平,左婷,王晓莉,孙汉巨,杨帆,王霄,张曼莉.灵芝草提取物的体内抗氧化活性研究[J].安徽农业科学,2013(25):10269-10271. |
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作者姓名: | 刘广平 左婷 王晓莉 孙汉巨 杨帆 王霄 张曼莉 |
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作者单位: | 安徽小刘食品股份有限公司,安徽合肥,230601;合肥工业大学生物与食品工程学院,安徽合肥,230009 |
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基金项目: | 2011年国家自然科学基金项目“31171787”;2012年安徽省长三角联合攻关项目“1201c0602005”. |
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摘 要: | 目的]研究灵芝草提取物的体内抗氧化活性.方法]以灵芝草提取物为原料,选用生理盐水为载体,Vc,下标作阳性对照,分别对小白鼠灌胃不同剂量的灵芝草提取物;30 d后,测定小白鼠的血清、肝脏及心脏中总抗氧化力(T-AOC)、谷胱甘肽(GSH)、超氧化物歧化酶(SOD)和谷胱甘肽过氧化酶(GSH-Px)的活力及丙二醛(MDA)和羟自由基含量,评价其体内抗氧化能力.结果]灵芝草提取物可以显著提高小白鼠血清、肝脏及心脏中的总抗氧化力(T-AOC)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化酶(GSH-Px)和谷胱甘肽(GSH).在20 ~ 500 kDa和10 ~ 20 kDa区间的提取物抗氧化效果最好.结论]灵芝草具有一定的体内抗氧化作用.
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关 键 词: | 灵芝草 提取物 膜分离 体内 抗氧 |
Study of in vivo Antioxidation Activity of Polyporus Lucidus Extracts |
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Institution: | LIU Guang-ping(Anhui Xiaoliu Food Company, Hefei, Anhui 230601) |
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Abstract: | Objective] To study in vivo antioxidative activity of polyporus lucidus extract.Method] With polyporus lucidus extract as raw material,physiological saline as carrier,and vitamin C as positive sample,mice were fed with different molecular weights of ganoderma lucidum.30 days later,after the animals were sacrificed,the spleen and thymus indexes were determined,and T-AOC,GSH,SOD,GSH-Px,MDA and content of hydroxyl free radical in serum,serum,liver and heart were determined.Result] The results showed that ganoderma lucidum extracts could increase the spleen and thymus indexes,and significantly increase T-AOC,SOD and GSH-Px,and GSH content.The extract of the molecular weights in 20-500 kDa and 10-20 kDa presented better antioxidative activity.Conclusion] Polyporus lucidus has the ability of in vivo antioxidation. |
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Keywords: | Polyporus lucidus Extract Membrane separation In vivo Antioxidation |
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