| 利福昔明的杂质A和杂质B的稳定性研究 |
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| 引用本文： | 刘超,胡昌勤,金少鸿.利福昔明的杂质A和杂质B的稳定性研究[J].安徽农业科学,2011,39(12):6947-6949,6996. |
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| 作者姓名： | 刘超 胡昌勤 金少鸿 |
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| 作者单位： | 中国药科大学,江苏南京,210009;中国药品生物制品检定所,北京,100050;南昌大学医学院药学系,江西南昌,330006;中国药品生物制品检定所,北京,100050 |
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| 摘 要： | 目的]研究自制的利福昔明杂质A和杂质B与利福昔明在不同条件下的变化规律。方法]在酸、碱、氧化、高温的条件下,采用高效液相色谱法测定利福昔明及其有关物质含量。结果]在1 mol/L HCl和1 mol/L NaOH溶液条件下,杂质A和杂质B均不稳定,在1 ml双氧水的条件下,杂质A非常稳定,而杂质B不稳定。杂质B在100℃下可部分转化为杂质A。结论]在较高温度下,杂质B可部分转化为杂质A,在酸、碱条件下杂质A和杂质B均不稳定。
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| 关 键 词： | 利福昔明 杂质A 杂质B 稳定性 |
Stability Research on the Impurity A and Impurity B of Rifaximin |
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| LIU Chao et al.Stability Research on the Impurity A and Impurity B of Rifaximin[J].Journal of Anhui Agricultural Sciences,2011,39(12):6947-6949,6996. |
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| Authors: | LIU Chao |
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| Institution: | LIU Chao et al (China Pharmaceutical University,Nanjing,Jiangsu 210009) |
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| Abstract: | Objective] To study the variation of the rifaximin and the two prepared impurities in different conditions.Method] The contents and related substances of the two unknown impurities were determined by RP-HPLC method in the condition of acid,alkali,oxidation and high temperature.Result] The two impurities were found very unstable in acid and alkali as 1M hydrochloric acid and 1M sodium hydroxide solution.But the impurity A was found very stable in the 1M hydrogen peroxide solution,nor the impurity B.And th... |
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| Keywords: | Rifaximin Impurity A Impurity B Stability |
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