鸡J亚群白血病病毒与网状内皮增殖病病毒混合感染发病机理的研究

通过人工感染建立了ALV—J、REV单独感染和混合感染1日龄肉仔鸡的病理模型。初步研究表明混合感染使试验鸡的生长发育障碍、免疫器官萎缩、对细菌易感性及死亡率等指标显著升高。 动态病理学研究表明：REV感染主要引起骨髓网状细胞及淋巴样细胞弥漫性或灶状浸润，ALV—J感染主要引起骨髓髓系细胞灶状或弥漫性显著增生，混合感染时骨髓病变与REV感染基本一致，但相对较严重，并见ALV—J感染病变。各病毒感染组免疫器官均发生了严重的实质萎缩性病变，病变以混合感染组最重，REV组次之。在某些组织器官ALV—J组见嗜酸性粒细胞样的瘤细胞浸润增生，REV组见网状细胞及淋巴细胞样瘤细胞浸润增生，而混合感染组见以上两种瘤细胞增生。从混合感染组的病变来看，在致病性上ALV—J与REV之间的确存在明显的协同促进作用，导致机体的免疫抑制加重，但混合感染早期尚未发现REV对ALV—J致瘤的促进作用。

STUDY ON THE PATHOGENESIS OF BROILERS COINFECTED WITH AVIAN LEUKOSIS VIRUS SUBGROUP J AND RETICULO ENDOTHELIOSIS VIRUS

Pathological model was established in one-day-old broilers that inoculated by avian leukosis virus subgroup J (ALV-J) strain NX0101, reticuloendotheliosis virus (REV) strain SD9901 and ALV-J + REV. Primary study showed thath ypogenesis of broilers;atrophy of immune organs;susceptible to bacterial agents;and lethality rate were much more serious in broilers infected with ALV-J + REV than in broilers infected alone with ALV-J or REV. Dynamic changes of pathology were studied on immune organs and some visceral organs The results showed that REV chiefly caused hyperplasia of reticulocytes and lymphocytes in bone marrow while ALVoJ mainly conduced hyperplasia of eosinocytes. The lesions of bone marrow in chickens infected with ALV-J + REV were more serious than that infected with REV alone, but different to that infected with ALV-J alone. The material atrophy lesions in immune organs was most serious in chickens infected with ALV-J + REV, then followed by chickens infected with REV. In some organs hyperplasia of tumorous eosinocytes in chickens infected with ALV-J and hyperplasia of tumorous reticulocytes with lymphocytes in chickens infected with REV were found,the both lesions in chikens infected with ALV-J +REV. However, it was not found that REV can accelerate the arise of tumors caused by ALV-J in early time.