| 生长抑素主动和被动免疫及基因免疫研究进展 |
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| 作者姓名： | 薛春林 茆达干 曹少先 孙大明 杨利国 |
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| 作者单位： | 南京农业大学动物繁育研究所，盐城市畜牧兽医研究所 江苏盐城224002，南京农业大学动物繁育研究所，南京农业大学动物繁育研究所，盐城市畜牧兽医研究所，南京农业大学动物繁育研究所，华中农业大学动物科技学院，湖北武汉430070，江苏南京210095，江苏南京210095，江苏南京210095，江苏盐城224002，江苏南京210095 |
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| 基金项目： | 国家自然科学基金“抑制素基因免疫效果影响因素的研究”（30270959）和南京农业大学校级青年创新基金“细菌DNA对抑制素基因免疫的作用效果”（y200411）. |
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| 摘 要： | 生长抑素(somatostatin,SS)是下丘脑释放的14肽激素,在动物体内具有广泛的抑制作用,特别是对生长及免疫反应具有明显的影响,通过耗竭或免疫中和体内的SS水平相应提高生长激素(GH)等水平促进动物生长。文中简要介绍了生长抑素主动和被动免疫的研究进展及基因免疫的作用机理、特点及增强基因免疫的途径;阐述了生长抑素基因疫苗的研究和应用发展前景。
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| 关 键 词： | 生长抑素 基因疫苗 免疫 机制 |
Progress in active and passive immunization against Somatostatin and its Gene |
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| Authors: | Xue Chunlin Mao Dagan Cao shaoxian Sun Daming Yang Liguo |
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| Institution: | (1Research Institute of Animal Breeding & Reproduction, Nanjing Agricultural University, Nanjing 210095,
2College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070,
3Institute of Animal Husbandry & Veterinary of Yancheng Ci |
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| Abstract: | Somatostain is a peptide hormone composed of 14 amino acids and secreted by hypothalamus. It acts in inhibition on growth. Exhaustion or immune neutralization of somatostain is able to improve growth hormone level and animal growth. In this paper, we briefly introduced the research progress in active and passive immunization against somatostatin or its gene,in mechanisms and characteristics as well as immune enhancement of the gene vaccine. Moreover, application and research prospect of somatostatin gene vaccine were described in detail. |
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| Keywords: | Somatostatin Gene vaccine Immunization Mechanism |
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