| 青光安颗粒剂对自发型青光眼小鼠眼压的影响 |
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| 作者姓名： | 项宇 刘家琪 李萍 彭俊 刘晓清 汤杰 喻娟 龙达 彭清华 |
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| 作者单位： | 湖南中医药大学第一附属医院中医眼科学重点学科, 湖南 长沙 410007,湖南中医药大学第一附属医院中医眼科学重点学科, 湖南 长沙 410007,湖南中医药大学第一附属医院中医眼科学重点学科, 湖南 长沙 410007,湖南中医药大学第一附属医院中医眼科学重点学科, 湖南 长沙 410007,湖南中医药大学第一附属医院中医眼科学重点学科, 湖南 长沙 410007,湖南中医药大学第一附属医院中医眼科学重点学科, 湖南 长沙 410007,湖南中医药大学第一附属医院中医眼科学重点学科, 湖南 长沙 410007,湖南中医药大学第一附属医院中医眼科学重点学科, 湖南 长沙 410007,湖南中医药大学第一附属医院中医眼科学重点学科, 湖南 长沙 410007 |
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| 基金项目： | 国家自然科学基金资助项目（81403437，81603665）；湖南省高层次卫生人才“225”工程培养项目资助；中国博士后基金面上资助项目（2015M570681）；湖南省自然科学基金资助项目（2015JJ3097）；湖南省教育厅科研基金优秀青年资助项目（14B137）；湖南省研究生创新基金重点资助项目（CX2013A013）；国家中医药管理局中医眼科学重点学科建设项目；湖南省中医五官科学重点学科建设项目。 |
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| 摘 要： | 目的 研究青光安颗粒剂在青光眼中对眼压的影响。方法 选用不同月龄共30只DBA/2J雌性小鼠，根据月龄采用随机数字表法分为3组，每组10只，20眼。分为正常对照组（3月龄）、模型对照组（9月龄）、青光安组（9月龄）。正常对照组与模型对照组每日以相同量蒸馏水灌胃；青光安组每日以青光安灌胃。3组均以常规饲料喂养。利用经前房注入/抽吸系统进行眼压测量，分别以2.5、5 μL/min的速率继续进行灌注，计算房水流畅系数和房水流出阻力。结果 自6月龄开始，小鼠眼压轻微上升，随着月龄的增加而逐步上升，9月龄时显著升高；青光安颗粒剂灌胃后所得眼压较模型组均有不同程度降低（P<0.05），房水流畅系数均明显增加（P<0.01），房水流出阻力均降低（P<0.01）。结论 青光安颗粒剂能通过影响房水动力学因素达到降低青光眼眼压的作用。
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| 关 键 词： | 青光安 青光眼 眼压 房水动力学 |
| 收稿时间： | 2017/6/15 0:00:00 |
| 修稿时间： | 2016/11/20 0:00:00 |
Effect of Qingguangan Granules on Intraocular Pressure of Spontaneous Glaucoma Mice |
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| Authors: | XIANG Yu LIU Jiaqi LI Ping PENG Jun LIU Xiaoqing TANG Jie YU Juan LONG Da and PENG Qinghua |
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| Institution: | The Key Disciplines of Phthalmology of Traditional Chinese Medicine, the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China,The Key Disciplines of Phthalmology of Traditional Chinese Medicine, the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China,The Key Disciplines of Phthalmology of Traditional Chinese Medicine, the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China,The Key Disciplines of Phthalmology of Traditional Chinese Medicine, the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China,The Key Disciplines of Phthalmology of Traditional Chinese Medicine, the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China,The Key Disciplines of Phthalmology of Traditional Chinese Medicine, the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China,The Key Disciplines of Phthalmology of Traditional Chinese Medicine, the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China,The Key Disciplines of Phthalmology of Traditional Chinese Medicine, the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China and The Key Disciplines of Phthalmology of Traditional Chinese Medicine, the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China |
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| Abstract: | To summarize the research progress of the surgical hip dislocation(SHD).The related literatures on SHD in terms of its history,indications,surgical technique and curative effect were summarized and analyzed.SHD significantly prolongs the degeneration of hip-joint,reduces necrosis rate of femoral head.However,there are some deficiency including non-union of greater trochanter and high rate of heterotopic ossification compared with traditional procedures after post-operation.SHD combined with related hip-preserving techniques can safely conduct hip intra-articular and extra-articular operations,remarkably enhance the longevity of hip-joint and has great clinical effects,which opens a new chapter for preservation of the hip considering its superior clinical results. |
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| Keywords: | Qingguangan granules glaucoma intraocular pressure aqueous humor dynamics |
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