益气养阴活血利水中药复方对兔视网膜脱离后视网膜组织中ATP含量的影响

目的 研究益气养阴活血利水中药复方（复明片）对兔实验性视网膜脱离后视网膜组织中ATP含量的影响。方法 将48只有色家兔随机分为正常对照组（A组）、模型对照组（B组）、西药对照组（C组）、复明片组（D组），每组12只。B、C、D组制作视网膜脱离模型。造模后第1天给药，A组、B组予温开水灌胃；C组予西药混合溶液灌胃，以上均1次/d；D组予复明片混悬液灌胃，1次/d。并于造模后7、21 d分别观察各组视网膜复位情况，取材后观察视网膜组织中ATP含量。结果 模型对照组视网膜组织ATP含量与正常对照组比较明显减少（P<0.01），与模型对照组比较，西药对照组和复明片治疗组ATP含量明显升高（P<0.01）。至术后第3周，复明片治疗组ATP含量已与正常对照组无明显差异（P>0.05）。结论 益气养阴活血利水中药复方（复明片）能改善视网膜脱离后视网膜组织的能量代谢，有助于视功能的恢复。

Effects of Yiqi Yangyin Huoxue Lishui Compound on ATP Contents in Retinal Tissue after Retinal Detachment of Rabbits

Objective To study the effects of Yiqi Yangyin Huoxue Lishui Compound (Fuming tablet) on ATP contents in retinal tissue after retinal detachment of rabbits.Methods 48 rats were randomly divided into normal control group (group A),model control group (group B),Western medicine control group (group C),FuMing tablet group (group D),12 rabbits in each group.The retinal detachment models were made in group B,C and D.After one day of modeling,the rabbits in group A and B were lavaged with warm water,the group C were lavaged with Western medicine solution,while group D were lavaged with Fuming tablet suspension,each group was lavaged once for one day,respectively.The retinal reattachment and ATP content of retinal tissue at 7th and 21st day were observed.Results Compared with the normal control group,the ATP content of retinal tissue in model group were decreased obviously (P<0.01).Compared with model group,ATP content of Western medicine group and Fuming tablet group was significantly increased (P<0.01).After three weeks of operation,the ATP content between normal group and Fuming tablet group has no significant difference (P>0.05).Conclusion Fuming Tablet could improve the energy metabolism of retina tissue after retinal detachment,and promote the recovery of visual function.