| 四君子汤对脾虚大鼠肝脏结构与功能的影响 |
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| 引用本文： | 王宁,郭凯军,甘静宜,朱晓宇,程飞,刘凤华,许剑琴.四君子汤对脾虚大鼠肝脏结构与功能的影响[J].北京农学院学报,2010,25(2):40-44. |
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| 作者姓名： | 王宁 郭凯军 甘静宜 朱晓宇 程飞 刘凤华 许剑琴 |
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| 作者单位： | 北京农学院动物科学技术学院,北京102206;兽医学中医药北京市重点实验室CAU-BUA TCVM教学与科研团队,北京102206;北京农学院动物科学技术学院,北京,102206;中国农业大学动物医学院中兽医实验室,北京,100193 |
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| 基金项目： | 国家自然科学基金，国家科技支撑计划，2009北京市教委学术创新团队项目 |
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| 摘 要： | 健康SD大鼠随机分为对照组、脾虚组、中药组（四君子汤治疗）。利血平诱导和建立大鼠脾虚模型，四君子汤进行治疗。组织学观察可见，脾虚大鼠肝细胞体积减小，核质比升高，脂肪空泡增多，肝索形态不可见；经四君子汤治疗后，肝细胞、肝索形态恢复，脂肪泡显著减少，且四君子汤有促进肝细胞增生作用。脾虚大鼠血清肝细胞损伤标志性指标ALT含量显著升高（P〈0．05）；AST显著降低（P〈0．05），脾虚情况下肝细胞损伤、线粒体功能下降；ALP含量显著降低（P〈0．05），肝脏合成ALP减少；GGT含量显著升高（P〈0．05），与肝细胞膜及肝内胆管上皮损伤相关。脾虚大鼠血清CHO，IBIL与TBA含量显著升高（P〈0．05），肝脏摄取转化和排泄胆固醇、胆红素和胆汁酸能力下降。由此可见，脾虚状态下大鼠肝脏受损，代谢胆红素及胆汁酸功能下降，脾虚黄疸为肝细胞性黄疸；四君子汤对脾虚大鼠肝脏结构改变有修复作用，一定程度回调肝功能指标，并促进肝脏代谢胆红素与胆汁酸能力恢复正常。
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| 关 键 词： | 四君子汤 脾虚 大鼠 肝细胞形态 肝脏功能 |
Liver Morphology and Serological Changes in Spleen-Deficiency Rat with Sijunzi Decoction |
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| WANG Ning,GUO Kai-jun,GAN Jing-yi,ZHU Xiao-yu,CHENG Fei,LIU Feng-hua,XU Jian-qin.Liver Morphology and Serological Changes in Spleen-Deficiency Rat with Sijunzi Decoction[J].Journal of Beijing Agricultural College,2010,25(2):40-44. |
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| Authors: | WANG Ning GUO Kai-jun GAN Jing-yi ZHU Xiao-yu CHENG Fei LIU Feng-hua XU Jian-qin |
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| Institution: | WANG Ning1,3,GUO Kai-jun1,GAN Jing-yi2,ZHU Xiao-yu2,CHENG Fei2,LIU Feng-hua1,XU Jian-qin2(1.Animal Science and Veterinary Medicine College,Beijing University of Agriculture,Beijing 102206,China,2.TCVM Laboratory,College of Veterinary Medicine,Agricultural University,Beijing 100193,3.Beijing Key Laboratory of TCVM CAU-BUA TCVM Teaching & Research Team,China) |
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| Abstract: | Healthy SD rats were randomly divided into control group,spleen deficiency group and Chinese herb treatment group(Sijunzi decoction treatment).Reseen-deficiency model in rats were treated with Sijunzi decoction.Histology observation revealed that compared with control group,hepatocytes of spleen deficiency group became small,nuclear-cytoplasmic ratio decreased;there were more intercellular fat bubbles.The normal appearance of hepatic cord disappeared.Sijunzi decoction recovered hepatocytes and reduced the n... |
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| Keywords: | Sijunzi decoction spleen deficiency rat hepatocyte histology hepatic function |
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