| 红曲固态发酵生产洛伐他汀的实验条件优化 |
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| 引用本文： | 沈平,伍军,李浩然,冯雅丽.红曲固态发酵生产洛伐他汀的实验条件优化[J].北京农学院学报,2005,20(3):47-51. |
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| 作者姓名： | 沈平 伍军 李浩然 冯雅丽 |
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| 作者单位： | 北京科技大学土木与环境工程学院,北京,100083;北京农学院食品科学系,北京,102206;中国科学院过程工程所生化工程国家重点实验室,北京,100080 |
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| 摘 要： | 笔者对洛伐他汀固态发酵的8个重要影响因素进行了正交实验设计, 并根据正交试验水平极差计算选取了高产洛伐他汀的优化水平组合, 即温度25 ℃, 周期11 d, 碳源为可溶性淀粉3%, 补水量自第3 天开始为10%, 不加硫酸镁, 0 1%磷酸二氢钾, 氮源为0 2% NaNO3, pH值4 5。
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| 关 键 词： | 红曲霉 洛伐他汀 固态发酵 正交试验 优化 |
| 文章编号： | 1002-3186(2005)03-0047-05 |
| 修稿时间： | 2005年1月10日 |
Optimization of Experimental Conditions on Lovastatin Yield Through Monascus |
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| SHEN Ping,WU Jun,LI Hao-ran,FENG Ya-li.Optimization of Experimental Conditions on Lovastatin Yield Through Monascus[J].Journal of Beijing Agricultural College,2005,20(3):47-51. |
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| Authors: | SHEN Ping WU Jun LI Hao-ran FENG Ya-li |
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| Abstract: | In this experiment,the operational factors on lovastatin yield by solid-state fermentation were studied by orthogonal design. The result showed that the optimum conditions was temperature 25℃, 11d of fermentation time, 3% of soluble starch as additive carbon source, 10% of water supplement from the third day, no MgSO (4)and 0.1% of KH (2)PO (4), 0.2% of NaNO (3) as additive nitrogen source and pH 4.5. |
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| Keywords: | monascus lovastatin solid-state fermentation orthogonal design optimization |
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