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mTOR Signaling Pathway and Its Regulation on Growth and Development
Authors:YANG Cairong  ZHENG Kejia  ZHANG Yan  LI Ning  LI Shufeng  YAN Yunqin
Institution:College of Life Sciences, Northeast Agricultural University, Harbin 150030, China
Abstract:The mammalian target of rapamycin (mTOR) signaling pathway is evolutionarily conserved. mTOR can integrate and converge a wide range of signals, including intracellular and extracellular nutrients, growth factors, energy and stress conditions, and has a crucial role in the vertebrate growth control. This review analyzed the main components and regulated factors of TOR signaling pathway, explained functions and mechanisms of mTOR during the individual growth, the development and its dynamic role, revealed it...
Keywords:mTOR  signaling pathway  growth and development  regulation  
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