mTOR Signaling Pathway and Its Regulation on Growth and Development |
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Authors: | YANG Cairong ZHENG Kejia ZHANG Yan LI Ning LI Shufeng YAN Yunqin |
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Institution: | College of Life Sciences, Northeast Agricultural University, Harbin 150030, China |
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Abstract: | The mammalian target of rapamycin (mTOR) signaling pathway is evolutionarily conserved. mTOR can integrate and converge a wide range of signals, including intracellular and extracellular nutrients, growth factors, energy and stress conditions, and has a crucial role in the vertebrate growth control. This review analyzed the main components and regulated factors of TOR signaling pathway, explained functions and mechanisms of mTOR during the individual growth, the development and its dynamic role, revealed it... |
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Keywords: | mTOR signaling pathway growth and development regulation |
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