| 牛基因组per microRNA SNP多态性 |
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| 引用本文： | 穆 松,钟金城,陈智华,徐利娟.牛基因组per microRNA SNP多态性[J].西北农业学报,2011,20(10):28-33. |
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| 作者姓名： | 穆 松 钟金城 陈智华 徐利娟 |
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| 作者单位： | 高原动物遗传育种与繁殖教育部重点实验室西南民族大学; |
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| 摘 要： | 研究牛microRNA的进化模式和现状,阐明microRNA的功能性SNP的作用和对动物表型的影响。选取牛per-microRNA及其相邻区域,统计各区域SNP数量和密度,考察SNP对microRNA二级结构稳定性和靶基因选择的影响。结果显示,per-microRNA的SNP密度显著低于其侧翼区,Seed区的SNP的密度较高,Seed区的SNP变异对per-microRNA二级结构稳定性的影响最高,microRNA成熟体SNP可能影响mi-croRNA对靶基因的选择。上述结果表明,牛在进化过程中可能存在加速进化的现象,目前牛microRNA的进化正处于活跃期。microRNA上的功能性SNP位点对microRNA的靶基因选择和结构稳定性有很大影响,并最终通过microRNA来影响动物表型的改变。
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| 关 键 词： | 牛 SNP microRNA |
Single Nucleotide Polymorphisms in Cattle Genomic Pre microRNA |
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| MU Song,ZHONG Jincheng,CHEN Zhihua and XU Lijuan.Single Nucleotide Polymorphisms in Cattle Genomic Pre microRNA[J].Acta Agriculturae Boreali-occidentalis Sinica,2011,20(10):28-33. |
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| Authors: | MU Song ZHONG Jincheng CHEN Zhihua and XU Lijuan |
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| Institution: | MU Song,ZHONG Jincheng,CHEN Zhihua and XU Lijuan(Key Laboratory of Plateau Animal Genetics,Breeding and Reproduction,Ministry of Education,Southwest University for Nationalities,Chengdu 610041,China) |
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| Abstract: | This study aims to study the evolution of cattle microRNA patterns and the status quo,to clarify the functional SNP on microRNA's role and influence of animal phenotype.Select cattle per-microRNA and its neighboring regions,statistics of the volume and density SNP regions to study SNP stability and secondary structure of microRNA target gene of choice.The SNP density in pre-microRNA regions was significantly lower in the flanking regions;seed zones of higher density SNP;the SNPs in the Seed regions showed g... |
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| Keywords: | Cattle Single nucleotide polymorphisms MicroRNA |
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