| 戈那瑞林在奶牛体内药物代谢动力学 |
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| 引用本文： | 刘 磊,李引乾,周广辉,邱瑾丽,张东兴,岑桂英,熊永洁,朱晓娟,关永娟,梁冠翔.戈那瑞林在奶牛体内药物代谢动力学[J].西北农业学报,2010,19(4):24-27. |
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| 作者姓名： | 刘 磊 李引乾 周广辉 邱瑾丽 张东兴 岑桂英 熊永洁 朱晓娟 关永娟 梁冠翔 |
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| 作者单位： | 1. 西北农林科技大学,动物医学院,陕西杨凌,712100
2. 宁波第二激素厂,浙江慈溪,315300 |
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| 摘 要： | 戈那瑞林(Cystorelin)为人工合成的促性腺激素释放激素(Gonadotropin-releasing hormone,GnRH)类似物。分析戈那瑞林在奶牛体内的药物代谢动力学过程,以期为兽医临床合理用药提供依据。试验前,对3头奶牛进行卵巢摘除手术,术后30 d单剂量肌肉注射戈那瑞林,在3 h内不同时间12次静脉采血,应用酶联免疫吸附法(ELISA)测定血清中促性腺激素释放激素(GnRH)质量浓度,以残数法拟合药-时曲线,计算药物动力学参数。结果显示,戈那瑞林在奶牛体内的药物动力学配置符合有吸收因素二室开放模型,其最佳药-时曲线方程为C=102.3426e-8.4166t+7.5778e-0.4014t-109.9204e-11.5226t。主要药物动力学参数分别为,消除相半衰期(t1/2β)(1.7311±0.1079)h、药-时曲线下面积(AUC)(21.5054±2.2476)ng/mL.h、峰质量浓度(Cmax)(16.2017±1.9901)ng/mL、达峰时间(tmax)(0.14±0.052)h。结果表明,奶牛肌肉注射戈那瑞林后,吸收快,消除也快。
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| 关 键 词： | 戈那瑞林 奶牛 药物代谢动力学 |
Pharmacokinetics of Cystorelin in Cow |
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| LIU Lei,LI Yinqian,ZHOU Guanghui,QIU Jinli,ZHANG Dongxing,CEN Guiying,XIONG Yongjie,ZHU Xiaojuan,GUAN Yongjuan and LIANG Guanxiang.Pharmacokinetics of Cystorelin in Cow[J].Acta Agriculturae Boreali-occidentalis Sinica,2010,19(4):24-27. |
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| Authors: | LIU Lei LI Yinqian ZHOU Guanghui QIU Jinli ZHANG Dongxing CEN Guiying XIONG Yongjie ZHU Xiaojuan GUAN Yongjuan and LIANG Guanxiang |
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| Institution: | LIU Lei1,LI Yinqian1,ZHOU Guanghui1,QIU Jinli1,ZHANG Dongxing1,CEN Guiying2,XIONG Yongjie1,ZHU Xiaojuan1,GUAN Yongjuan1 , LIANG Guanxiang1 (1.College of Veterinary Medicine,Northwest A&F University,Yangling Shaanxi 712100,China,2.Ningbo Second Hormone Factory,Cixi Zhejiang 315300,China) |
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| Abstract: | Cystorelin is a synthetic analogue of gonadotropin-releasing hormone(GnRH).In order to provide theoretical basis of rational drug used for veterinary clinical,the pharmacokinetic course of Cystorelin in cow was analyzed.Three cows after ovariectomy were treated with a single dosage of injection of Cystorelin,and 12 blood samples of vein were collected within three hours after giving drug.The concentrations of Cystorelin in serum were determined by ELISA.The two-compartment model with absorption factor adequ... |
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| Keywords: | Cystorelin Cow Pharmacokinetics |
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