| 复方替米考星纳米乳的制备及其品质评价 |
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| 引用本文： | 王 璟,欧阳五庆,傅 晨,商育锦.复方替米考星纳米乳的制备及其品质评价[J].西北农业学报,2011,20(4):35-39. |
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| 作者姓名： | 王 璟 欧阳五庆 傅 晨 商育锦 |
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| 作者单位： | 西北农林科技大学动物医学院,陕西杨凌,712100 |
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| 基金项目： | 陕西省重大科技创新专项基金 |
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| 摘 要： | 制备复方替米考星纳米乳并对其品质进行评价。通过绘制伪三元相图优选处方,以替米考星、氟苯尼考、吐温-80、肉豆蔻异丙酯(IPM)、无水乙醇、1,2-丙二醇(PG)和柠檬酸为原料,制备复方替米考星纳米乳,并考察其结构类型、形态及粒径、稳定性。结果表明,复方替米考星纳米乳透射电镜下呈球形,平均粒径为15.4 nm,多分散系数(PDI)为0.08,粒径分布均匀,稳定性试验显示其未分层,仍为澄清透明纳米乳状液。由试验结果可知,复方替米考星纳米乳稳定性好,制备工艺简单,有望应用于兽医临床。
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| 关 键 词： | 替米考星 氟苯尼考 纳米乳 伪三元相图 品质评价 |
Preparation and Quality Evaluation of Compound Tilmicosion Nanoemulsion |
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| WANG Jing,OUYANG Wuqing,FU Chen and SHANG Yujin.Preparation and Quality Evaluation of Compound Tilmicosion Nanoemulsion[J].Acta Agriculturae Boreali-occidentalis Sinica,2011,20(4):35-39. |
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| Authors: | WANG Jing OUYANG Wuqing FU Chen and SHANG Yujin |
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| Institution: | WANG Jing,OUYANG Wuqing,FU Chen and SHANG Yujin(College of Veterinary Medicine,Northwest A&F University,Yangling Shaanxi 712100,China) |
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| Abstract: | This paper is to study the preparation and quality evaluation of compound tilmicosin and florfenicol nanoemulsion.The formulations of compound tilmicosin and florfenicol nanoemulsion were optimized by protracting the pseudoternary phase diagrams.Tilmicosin,florfenicol,tween 80,Isopropyl myristate(IPM),absolute ethyl alcohol,propylene glycol,citric acid were selected to prepare compound tilmicosin and florfenicol nanoemulsion.Its structural type,appearance,particle size and physical stability were tested res... |
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| Keywords: | Timicosion Florfenicol Nanoemulsion Pseudoternary phase diagram Quality evaluation |
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