| 中年CD-1小鼠背海马syntaxin 1水平的改变 |
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| 引用本文： | 姚明仁,何燕,陈贵海.中年CD-1小鼠背海马syntaxin 1水平的改变[J].安徽农业大学学报,2013,40(2):196. |
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| 作者姓名： | 姚明仁 何燕 陈贵海 |
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| 作者单位： | 安徽医科大学第一附属医院神经内科,合肥230022 |
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| 基金项目： | 国家自然科学基金项目（30872730）和安徽省自然科学基金(09020103001）共同资助。 |
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| 摘 要： | 应用免疫组化技术检测13月龄(中年)和5月龄CD-1小鼠背海马突触前蛋白syntaxin 1的表达水平.结果显示,13月龄小鼠齿状回、CA1及CA3区各层syntaxin 1的相对含量较5月龄均显著下降.表明中年CD-1小鼠背海马syntaxin 1含量全面下调.
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| 关 键 词： | 衰老 海马 免疫组化 小鼠 syntaxin |
Changed syntaxin 1 level in dorsal hippocampus of the middle-aged CD-1 mice |
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| YAO Ming-ren,HE Yan and CHEN Gui-hai.Changed syntaxin 1 level in dorsal hippocampus of the middle-aged CD-1 mice[J].Journal of Anhui Agricultural University,2013,40(2):196. |
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| Authors: | YAO Ming-ren HE Yan and CHEN Gui-hai |
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| Institution: | Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022,Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022 and Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022 |
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| Abstract: | Using immunohistochemistry method, the level of syntaxin1 in drosal hippocampus of the CD-1 mice at age of 5-month and 13-month (middle-aged) was explored. The result showed that the 13-month-old mice had significantly lower level of syntaxin1 in all stratums of dentate gyrus, CA1 and CA3 subfields in drosal hippocampus in comparsion with the 5-month-old mice. The result suggest that there is reduced syntaxin1 in the dorsal hippocampus of the middle-aged CD-1 mice. |
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| Keywords: | aging hippocampus immunohistochemistry mouse syntaxin |
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