| 40株虫生真菌菌丝体提取物抗肿瘤活性的初步研究 |
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| 引用本文： | 何亚琼,胡丰林,李春如,左登平,刘玉军,樊美珍.40株虫生真菌菌丝体提取物抗肿瘤活性的初步研究[J].安徽农业大学学报,2008,35(1):84-88. |
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| 作者姓名： | 何亚琼 胡丰林 李春如 左登平 刘玉军 樊美珍 |
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| 作者单位： | 安徽农业大学微生物防治省重点实验室,合肥,230036 |
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| 基金项目： | 国家自然科学基金
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安徽省自然科学基金 |
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| 摘 要： | 以中国仓鼠卵巢(CHO)细胞株为模型,用Resazurin法检测生长抑制率,对40株虫生真菌菌丝体的提取物进行体外抗肿瘤活性试验.结果表明,黄山被毛孢Hirsutella huangshanensis菌株RCEF0851和RCEF0868菌丝体提取物对CHO细胞株的抑制活性最强,其乙酸乙酯和二氯甲烷混合溶剂提取物在100 μg·mL-1时对CHO细胞的抑制率分别为(98.58±1.12)%、(98.47±2.11)%;其甲醇提取物在100 μg·mL-1浓度时对CHO细胞的抑制率也分别达到(97.30±1.83)%和(96.28±1.96)%.复筛的结果表明,RCEF0851和RCEF0868菌丝体提取物对CHO细胞的半数抑制浓度IC50分别为29.24 μg·mL-1和28.87 μg·mL-1.另外,环链拟青霉Paecilomyces cateniannulatus菌株RCEF0508菌丝的乙酸乙酯和二氯甲烷混合溶剂提取物在100 μg·mL-1时对CHO细胞的抑制率也达(95.96±2.01)%,这些菌株值得进一步深入研究.
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| 关 键 词： | 虫生真菌 抗肿瘤活性 CHO细胞 |
| 文章编号： | 1672-352X（2008）01-0084-05 |
| 收稿时间： | 2007-04-24 |
| 修稿时间： | 2007年4月24日 |
Antitumor activities of extracts from mycelium of 40 entomogenous fungi |
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| HE Ya-qiong,HU Feng-lin,LI Chun-ru,ZUO Deng-ping,LIU Yu-jun,FAN Mei-zhen.Antitumor activities of extracts from mycelium of 40 entomogenous fungi[J].Journal of Anhui Agricultural University,2008,35(1):84-88. |
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| Authors: | HE Ya-qiong HU Feng-lin LI Chun-ru ZUO Deng-ping LIU Yu-jun FAN Mei-zhen |
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| Institution: | Pudong Business Administrative College of Shanghai Maritime University |
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| Abstract: | Any translation involving two languages is by no means referred to as a simple transference between two languages, but greatly influenced by the different characteristics of each language. In English- Chinese translation activities, the influence of the differences between English and Chinese will have a great effect on the meaning transference in the process of translation. It includes three aspects such as difference in vocabulary, sentence structural difference and cultural difference. |
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| Keywords: | entomogenous fungi antitumor activity CHO cells |
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