| 长期口服阿卡波糖对SAMP8小鼠背海马synaptotagmin Ⅰ的影响 |
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| 引用本文： | 随旭,陶飞,童晶晶,陈贵海.长期口服阿卡波糖对SAMP8小鼠背海马synaptotagmin Ⅰ的影响[J].安徽农业大学学报,2014,41(2):287-289. |
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| 作者姓名： | 随旭 陶飞 童晶晶 陈贵海 |
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| 作者单位： | 安徽医科大学第一附属医院神经内科,合肥230022;安徽医科大学第一附属医院神经内科,合肥230022;安徽医科大学第一附属医院神经内科,合肥230022;安徽医科大学第一附属医院神经内科,合肥230022 |
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| 基金项目： | 国家自然科学基金（30872730, 81370444）和安徽省高校省级自然科学重点项目（ZD2008007-1）共同资助。 |
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| 摘 要： | 利用免疫组化法检测长期口服阿卡波糖对SAMP8小鼠背海马突触蛋白synaptotagminⅠ（SytⅠ）表达的影响。结果显示，SytⅠ在背海马CA1、CA3区和齿状回各层均有表达。老年对照组小鼠背海马各区SytⅠ的相对含量显著高于青年对照组（Ps<0.05）。阿卡波糖处理组小鼠背海马各区SytⅠ的相对含量显著低于同龄对照组（Ps<0.05）。上述结果提示长期口服阿卡波糖可减轻SAMP8小鼠背海马年龄相关性SytⅠ增加的水平。
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| 关 键 词： | 衰老 阿卡波糖 海马 小鼠 synaptotagmin |
| 收稿时间： | 9/5/2013 12:00:00 AM |
Effects of orally chronic administration of acarbose on synaptotagmin I level in dorsal hippocampus of the SAMP8 mice |
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| SUI Xu,TAO Fei,TONG Jingjing and CHEN Guihai.Effects of orally chronic administration of acarbose on synaptotagmin I level in dorsal hippocampus of the SAMP8 mice[J].Journal of Anhui Agricultural University,2014,41(2):287-289. |
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| Authors: | SUI Xu TAO Fei TONG Jingjing and CHEN Guihai |
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| Institution: | Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022,Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022,Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022 and Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022 |
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| Abstract: | In this study, the effect of orally chronic administration of acarbose on synaptotagmin I (Syt I) level in dorsal hippocampus of the SAMP8 mice was explored using immunohistochemical method. The results indicated that Syt I was expressed in CA1 and CA3 subfields and dentate gyrus of the dorsal hippocampus. The relative amount of Syt I in the elderly control group was significantly higher than that in the young control group in each subfields of the dorsal hippocampus (Ps<0.05). However, the acarbose-treated mice had significantly lower level of Syt I in all subfields in comparison with the elderly control mice (Ps<0.05). Our results suggest that orally chronic administration of acarbose could reduce the age-related increase of Syt I in the dorsal hippocampus of the SAMP8 mice. |
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| Keywords: | aging acarbose hippocampus mouse synaptotagmin |
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