青年期心理社会环境改变对中老年小鼠焦虑 和自发探索活性的影响

探索青年期心理社会环境改变对中老年CD-1小鼠焦虑和自发探索活性行为的影响。结果表明,与青年组(3月龄)比较,老年对照组(18月龄)在旷场潜伏期和周边时间显著延长,跨格子数显著减少(Ps0.05);在黑白巷黑端时间和潜伏期显著延长,黑端到白端次数显著减少(Ps0.05)。12月龄应激组在旷场周边时间和在黑白巷黑端时间显著长于丰富环境组和对照组,跨越格子数显著减少(Ps0.05)。18月龄应激组在旷场周边时间和在黑白巷黑端时间、潜伏期显著长于丰富环境组(Ps0.05)。这些提示CD-1小鼠焦虑行为改变具有年龄依赖性,青年期心理社会环境改变可调节小鼠年龄相关性焦虑和自发探索活性行为的改变。

Effect of psychosocial environment change on anxiety and locomotor behaviors of the middle-aged CD-1 mice

The aim of the present study was to investigate whether adolescent psychosocial environment affects anxiety and locomotor behaviors in the middle-aged CD-1 mice. The latency and peripheral time significantly increased, and the number of squares crossed in the open field significantly decreased (Ps < 0.05) in the 18 months old control mice (old) than those in the 3 months old control mice (young). In the black-white alley task, the old control group also had a significantly longer latency and time spent in the black alley, and a lower number from the black to white alley than the young control group (Ps < 0.05). At 12 months old, the stressed group had a significantly increased time spent in the black alley of black-white alley and peripheral time in the open-field than the control group and enriched-environment group (Ps < 0.05), but the stressed group had a decreased square crossed number in the open-field (Ps < 0.05). At the 18 months old, the stressed group had more peripheral time, latency and time spent in the black alley than the enriched-environment group only (Ps < 0.05). The above results suggested that changes of anxious behavior in the CD-1 mice were age-dependent and chronic changes of psychosocial environments during adolescent-youth could modulate the age-related increase of anxiety and decline of locomotor activity in the middle-aged CD-1 mice.