| 青春期双酚A暴露对老年CD-1小鼠海马齿状回Synaptotagmin 1含量的影响 |
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| 引用本文： | 吴鹏超,陈贵海,葛海,随旭.青春期双酚A暴露对老年CD-1小鼠海马齿状回Synaptotagmin 1含量的影响[J].安徽农业大学学报,2014,41(4):597. |
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| 作者姓名： | 吴鹏超 陈贵海 葛海 随旭 |
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| 作者单位： | 安徽医科大学第一附属医院神经内科,合肥230022;安徽医科大学第一附属医院神经内科,合肥230022;安徽医科大学第一附属医院神经内科,合肥230022;安徽医科大学第一附属医院神经内科,合肥230022 |
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| 基金项目： | 国家自然科学基金（30872730, 81370444）资助。 |
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| 摘 要： | 探讨青春期双酚A暴露对老年期齿状回Synaptotagmin 1（Syt 1）含量的影响。结果显示，18月龄CD-1小鼠齿状回Syt 1相对含量显著高于6月龄小鼠（Ps<0.05）；青春期双酚A暴露高剂量小鼠齿状回Syt 1表达量显著高于同年龄对照小鼠（Ps<0.05），雌鼠更明显。这些结果进一步支持小鼠海马Syt 1呈年龄相关性增加的结论，青春期双酚A暴露可加剧这种增加。
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| 关 键 词： | 衰老 双酚A 海马 齿状回 Synaptotagmin 1 |
| 收稿时间： | 2014/4/15 0:00:00 |
Effect of exposure to bisphenol A during puberty on synaptotagmin 1 level in dentate gyrus of dorsal hippocampus in the aged CD-1 mice |
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| WU Pengchao,CHEN Guihai,GE Hai and SUI Xu.Effect of exposure to bisphenol A during puberty on synaptotagmin 1 level in dentate gyrus of dorsal hippocampus in the aged CD-1 mice[J].Journal of Anhui Agricultural University,2014,41(4):597. |
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| Authors: | WU Pengchao CHEN Guihai GE Hai and SUI Xu |
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| Institution: | Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022,Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022,Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022 and Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022 |
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| Abstract: | This study was to explore the effect of exposure to bisphenol A during puberty on synaptotagmin (Syt) 1 level in dentate gyrus of dorsal hippocampus in aged CD-1 mice. The results showed that the expression level of Syt 1 in the 18-month control mice was significantly higher than that in the 6-month control mice (P <0.05). The Syt 1 level of dentate gyrus in the 18-month mice exposed to bisphenol A during adolescent significantly increased compared to the same-age control mice (P <0.05), especially in the females. These results further supported the conclusion that the increase of Syt 1 was age-related in dorsal hippocampus. Bisphenol A exposure during puberty may exacerbate such an increase. |
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| Keywords: | aging bisphenol A hippocampus synaptotagmin-1 |
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