| 动物中几种主要谷胱甘肽S-转移酶亚型的研究进展 |
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| 引用本文： | 吴炯,赵荣涛,何建瑜,刘慧慧.动物中几种主要谷胱甘肽S-转移酶亚型的研究进展[J].浙江水产学院学报,2014(3):278-283. |
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| 作者姓名： | 吴炯 赵荣涛 何建瑜 刘慧慧 |
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| 作者单位： | 浙江海洋学院海洋科学与技术学院,国家海洋设施养殖工程技术研究中心,浙江舟山316022 |
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| 基金项目： | 国家科技支撑计划项目（2011BAD138081;国家星火.汁划项目（2012GA700111）;浙江省海洋与渔业项目（浙海渔计（2012）83号） |
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| 摘 要： | 谷胱甘肽s-转移酶是生物体内一类重要的解毒酶，主要在抗毒机制第Ⅱ阶段起作用，在许多脊椎动物和无脊椎动物中参与免疫防御和代谢过程，已作为生物标记基因而广泛用于环境污染评估。本文阐述了胞质中几种主要谷胱甘肽s-转移酶亚型的生物学性质和作用，及其国内外研究的最新进展，以期为进一步开发谷胱甘肽s-转移酶提供指导。
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| 关 键 词： | 谷胱甘肽s-转移酶 亚型 污染评估 进展 |
Advancement of Research on Several Major Subtypes of Glutathione S-transferase in Animals |
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| Institution: | WU Jiong, ZHAO Rong-tao, HE Jian-yu, et al (Marine Science and Technology School of Zhejiang Ocean University, National Engineering Research Center of Marine Facilities Aquaculture, Zhoushan 316022, China) |
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| Abstract: | Glutathione S-Transferases （GSTs） are important detoxification enzymes in living organisms, which belong to the superfamily of phase II detoxification enzymes, and play crucial roles in many immune and metabolic processes of vertebrates and invertebrates. Currently, GSTs are widely used as biomarkers of environmental pollution assessment. This paper described the biological nature and roles of several major cytoplas- mic body glutathione S-transferase isoforms, and reviewed the latest research of them at home and abroad to provide guidance for the further development of glutathione S-transferase （GST） applications. |
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| Keywords: | Glutathione S-transferase subtypes contamination assessment progress |
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