| 新型4-氨基安替比林席夫碱的合成、表征和抑菌活性 |
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| 引用本文： | 张淼,许玮,任俊杰,朱华玲,白亚南,王学荣.新型4-氨基安替比林席夫碱的合成、表征和抑菌活性[J].天津农学院学报,2012,19(1):30-33. |
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| 作者姓名： | 张淼 许玮 任俊杰 朱华玲 白亚南 王学荣 |
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| 作者单位： | 天津农学院基础科学系,天津,300384 |
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| 基金项目： | 天津农学院大学生科研创新项目“新型β-二酮类席夫碱金属配合物的合成与生物活性研究” |
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| 摘 要： | 合成了3种新型芳基吡唑酮（1-苯基-3-甲基-4-乙酰基-5-吡唑啉酮、1-苯基-3-甲基-4-甲酰-5-Cl-吡唑和苯甲酰丙酮）缩4-氨基安替比林席夫碱，对合成的化合物进行了元素分析、光谱分析（红外和紫外）以及HNMR分析。采用纸片扩散法，测试了化合物对大肠杆菌和枯草芽孢杆菌的抗茵活性。结果表明，所有化合物都有一定的抑制大肠杆菌和枯草芽孢杆菌生长的活性。
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| 关 键 词： | 安替比林 席夫碱 合成表征 抑菌活性 |
Synthesis, Characterization and Antibacterial Study of Some New 4-Amino Antipyrine Schiff Bases |
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| ZHANG Miao,Xv Wei,REN Jun-jie,ZHU Hua-ling BAI Ya-nan,WANG Xue-rong.Synthesis, Characterization and Antibacterial Study of Some New 4-Amino Antipyrine Schiff Bases[J].Journal of Tianjin Agricultural College,2012,19(1):30-33. |
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| Authors: | ZHANG Miao Xv Wei REN Jun-jie ZHU Hua-ling BAI Ya-nan WANG Xue-rong |
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| Institution: | (Department of Basic Courses,Hanjin Agricultural University,Tianjin 300384,China) |
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| Abstract: | Three new Schiff bases derived from L1（where L1=-pheny1-3-methyl-4-acetyl-5-pyrazolone, 1-phenyl-3-methyl-4-formyl-5-Cl-pyrazole and benzoylacetone ） and 4- Amino antipyrine have been prepared and characterized by elemental analysis,spectroscopic data（IR and UV） and HNMR.The antibacterial activity tests of the compounds at different concentrations against Bacillus coli and Bacillus subtilis were performed by using disc diffusion method.The results indicate that almost all compounds have the activity of inhibiting the growth of the two bacteria. |
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| Keywords: | antipyrine schiffbases synthesis and characterization antibacterial study |
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