| 附子-甘草对离体蛙心的影响及其指纹图谱研究 |
| |
| 作者姓名： | 张序晴 彭兰 李赛 李耀伟 喻阳 曾嵘 任卫琼 邓凯文 王志琪 |
| |
| 作者单位： | 湖南中医药大学研究生院, 湖南 长沙 410208,湖南中医药大学研究生院, 湖南 长沙 410208,湖南中医药大学研究生院, 湖南 长沙 410208,湖南中医药大学研究生院, 湖南 长沙 410208,湖南中医药大学湘杏学院, 湖南 长沙 410208,湖南中医药大学药学院, 湖南 长沙 410208,湖南中医药大学附属第一医院, 湖南 长沙 410000,湖南中医药大学附属第一医院, 湖南 长沙 410000,湖南中医药大学药学院, 湖南 长沙 410208;湖南省中药饮片标准化及功能工程技术中心, 湖南 长沙 410208 |
| |
| 基金项目： | 国家自然科学基金项目（81503492，81473617）；湖南省自然科学基金项目（2015JJ6079）；湖南省教育厅教改项目（湘教通〔2016〕400-321）；湖南中医药大学教改项目（2018-JG021） |
| |
| 摘 要： | 目的 研究附子-甘草合煎液和混合液对离体蛙心的影响及其物质基础。方法 通过离体蛙心实验观察附子-甘草合煎液和混合液对离体正常蛙心和心衰蛙心功能的影响，应用高效液相色谱法建立并测定附子-甘草煎液的HPLC指纹图谱。结果 附子-甘草合煎液与混合液的强心作用有差别；附子与甘草配伍后其指标成分的含量发生了明显变化，且合煎液与混合液的成分变化差别显著。结论 附子-甘草合煎液和混合液对离体蛙心的作用及其指纹图谱均不一致。
|
| 关 键 词： | 附子 甘草 离体蛙心 指纹图谱 合煎液 混合液 |
| 收稿时间： | 2018/9/13 0:00:00 |
Effect of Aconite-Licorice on the Isolated Frog Heart and Its Fingerprint |
| |
| Authors: | ZHANG Xuqing PENG Lan LI Sai LI Yaowei YU Yang ZENG Rong REN Weiqiong DENG Kaiwen and WANG Zhiqi |
| |
| Institution: | Graduate School, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China,Graduate School, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China,Graduate School, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China,Graduate School, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China,Xiangxing College, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China,School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China,The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410000, China,The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410000, China and School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Hunan Provincial Traditional Chinese Medicine Decoction Pieces Standardization and Functional Engineering Technology Center, Changsha, Hunan 410208, China |
| |
| Abstract: | Objective To explore the effects of aconite-licorice combined decoction and aconite-licorice mixed liquid on the isolated frog heart and their material basis. Methods The effects of aconite-licorice combined decoction and aconite-licorice mixed liquid on the isolated normal and failing frog hearts were evaluated by isolated frog heart experiment. Their HPLC fingerprints were established and compared. Results There was a difference in the cardiotonic effect between aconite-licorice combined decoction and aconite-licorice mixed liquid. The content of index components changed significantly after the combination of aconite and licorice, and there was a significant difference in component changes between the combined decoction and the mixed liquid. Conclusion Aconite-licorice combined decoction and aconite-licorice mixed liquid have different effects on the isolated frog heart as well as different fingerprints. |
| |
| Keywords: | aconite licorice isolated frog heart fingerprint decoction mixture |
|
| 点击此处可从《》浏览原始摘要信息 |
| 点击此处可从《》下载免费的PDF全文 |
|
