| 血竭素对瘢痕成纤维细胞增殖的影响 |
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| 引用本文： | 张培华,罗少军,汤少明,肖佐环,梁杰,左强,李瑾.血竭素对瘢痕成纤维细胞增殖的影响[J].湛江医学院学报,2005,23(4):361-363. |
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| 作者姓名： | 张培华 罗少军 汤少明 肖佐环 梁杰 左强 李瑾 |
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| 作者单位： | 广东医学院附属医院整形外科,广东湛江524001;广东省成人科技大学,广东广州510520;中山大学附属第五医院皮肤科,广东珠海519000 |
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| 基金项目： | 教育部科学技术研究重点项目（编号：205114）;广东省自然科学基金资助项目（编号：036736）;广东省中医药局科研课题资助项目（编号：103074）;湛江市2003年科技招标资助项目 |
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| 摘 要： | 目的：观察天然药物血竭素高氯酸盐（dracorhodin perchlorate．Dp）对瘢痕成纤维细胞增殖的影响。方法：用四甲基偶氟唑（MTT）比色法和流式细胞术（FCM）分别检测成纤维细胞的抑制率和细胞周期。结果：MTT法显示Dp对成纤维细胞的抑制率增高、且呈现浓度和时间依赖性（P〈0.01）。FCM检测增殖指数，呈剂量依赖性降低（P〈0．01）。结论：Dp对瘢痕成纤维细胞的增殖具有显著的抑制作用。
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| 关 键 词： | 血竭素高氯酸盐 成纤维细胞 增殖 |
| 文章编号： | 1005-4057(2005)04-0361-03 |
| 收稿时间： | 03 21 2005 12:00AM |
| 修稿时间： | 04 25 2005 12:00AM |
Effect of dracorhodin perchlorate on proliferation of scar-derived fibroblasts |
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| Zhang PeiHua;Luo ShaoJun;Shang ShaoMing;Xiao ZuoHuan;Liang Jie;Zuo Jiang;Li Jin.Effect of dracorhodin perchlorate on proliferation of scar-derived fibroblasts[J].Journal of Guangdong Medical College,2005,23(4):361-363. |
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| Authors: | Zhang PeiHua;Luo ShaoJun;Shang ShaoMing;Xiao ZuoHuan;Liang Jie;Zuo Jiang;Li Jin |
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| Abstract: | Objective:To observe the effect of herbal medici ne dracorhodin per chlorate (DP) on proliferation of scar-derived fibroblasts. Methods: The fibrobl asts were cultured with DP and then the cell growth rate was determined with MTT assay and the proliferation index was measured with flow cytometry (FCM), respe ctively.Results:Compared with the control group, the fibroblasts significantly reduced their growth rate (according to MTT assay) and proliferation index (acc ording to FCM measurement) after exposed to DP in a concentration and time-depe n dent manner, respectively for both,( P<0.01).Conclusion:D P could be a potential inhibitor of proliferation of cultured fibroblasts. |
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| Keywords: | dracorhodin perchlorate fibroblasts proliferation |
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