| 苯甲酸雌二醇对L-谷氨酸单钠损毁弓状核雌性大鼠血脂代谢的影响 |
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| 引用本文： | 钟平,张兆强,蔡波,刘古锋,刘锡仪.苯甲酸雌二醇对L-谷氨酸单钠损毁弓状核雌性大鼠血脂代谢的影响[J].湛江医学院学报,2009,27(1):9-10. |
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| 作者姓名： | 钟平 张兆强 蔡波 刘古锋 刘锡仪 |
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| 作者单位： | 广东医学院生理学教研室,广东湛江,524023
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| 摘 要： | 目的观察苯甲酸雌二醇（EB）对L广谷氨酸单钠（MSG）损毁弓状核雌性大鼠体质量、脂肪湿质量及血脂代谢的影响。方法皮下注射MSG建立新生SD雌性大鼠弓状核损毁模型。造模大鼠于30日龄时分别肌肉注射EB0．24mg／kg（MSG＋EBL组）、0．48mg／kg（MSG＋EBH组），隔天1次，共30次；停止注射后15d处死大鼠，检测体质量、脂肪湿质量、血脂、血清雌二醇（E2）。结果模型组大鼠体质量、脂肪湿质量／体质量、血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL—C）都明显升高（P〈0．05），而E2、高密度脂蛋白胆固醇（HDL-C）显著降低（P〈0．05）。EB处理后大鼠的体质量、脂肪湿质量／体质量、TC、TG、LDL-C均显著回降（P〈0．05），而E2、HDL—C显著回升（P〈0．05）；MSG＋EBH组与MSG＋EBI组比较，其各项指标差异均无统计学意义（P〉0．05）。结论EB对弓状核损毁的雌性大鼠血脂代谢紊乱有治疗作用。
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| 关 键 词： | L-谷氨酸单钠 SD大鼠 苯甲酸雌二醇 血脂 |
Effect of estradiol benzoate on serum lipid metabolism in female rats with arcuate nucleus lesion |
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| ZHONG Ping,ZHANG Zhao-qiang,CAI Bo,LIU Gu-feng,LIU Xi-yi.Effect of estradiol benzoate on serum lipid metabolism in female rats with arcuate nucleus lesion[J].Journal of Guangdong Medical College,2009,27(1):9-10. |
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| Authors: | ZHONG Ping ZHANG Zhao-qiang CAI Bo LIU Gu-feng LIU Xi-yi |
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| Institution: | Department of Physiology;Guangdong Medical College;Zhanjiang 524023;China |
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| Abstract: | Objective To investigate the effect of estradiol benzoate(EB) on body weight,wet fat weight and serum lipid metabolism in female rats with arcuate nucleus damaged by monosodium glutamate(MSG).Methods Arcuate nucleus lesion models were established by subcutaneous injection of MSG in newborn SD female rats.The 30-day-old model rats commenced to receive intramuscular injection of EB at a dose of 0.24 mg/kg(MSG+EBL group) or 0.48 mg/kg(MSG+EBH group) on alternate day for 30 days.All rats were sacrificed 15 days... |
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| Keywords: | monosodium glutamate SD rat estradiol benzoate serum lipid |
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