粘附分子CD44v6在宫颈癌组织中的表达及意义

目的:了解粘附分子CD44v6在宫颈癌组织中的表达及其意义。方法:采用免疫组织化学法(SP法)检测CD44v6在69例宫颈癌组织及20例正常宫颈组织中的表达。结果:正常宫颈组织中的CD44v6呈阴性表达。69例宫颈癌组织中CD44v6的阳性表达率为68.1％(47/69)。CD44v6的阳性表达在不同的病灶大小、临床分期、细胞分化程度及有无淋巴结转移的宫颈癌组织中差异有统计学意义(P<0.05～0.01);在不同的病理类型及年龄的患者中差异无统计学意义(P>0.05)。结论;CD44V6可能在宫颈癌的生长、浸润及转移过程中起重要作用,可望作为反映宫颈癌恶性潜能的新指标。

CD44v6 expression in cervical carcinoma and its clinical significance

Objective: To investigate CD44v6 expression in cervical carcinoma and its clinical significance. Methods; CD44v6 expression was detected by immunohistochemical method in 69 cervical cancers and 20 normal cervical specimens. Results: CD44v6 was expressed in 47 (68. 1%) cervical cancers, but not in normal cervical tissues. Except for pathological type and patients' age, CD44v6 expression was significantly correlated with lesion size, clinical staging, cell differentiation and nodal metastasis (P<0. 01~0. 05). Conclusion: CD44v6 may play an important role in the growth, invasion and metastasis of cervical carcinoma, which is expected to be a new marker for judging its malignant potential.