| 厄贝沙坦对原发性高血压患者左心室肥厚及心率变异性的影响 |
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| 引用本文： | 许锦荣,莘筑,曾坚,张凌.厄贝沙坦对原发性高血压患者左心室肥厚及心率变异性的影响[J].湛江医学院学报,2009,27(3):255-257. |
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| 作者姓名： | 许锦荣 莘筑 曾坚 张凌 |
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| 作者单位： | 许锦荣,莘筑,曾坚,XU Jin-rong,XIN Zhu,ZENG Jian(广东医学院第二附属医院,内科,广东湛江,524003);张凌,ZHANG Lin(广东医学院第二附属医院,特检科,广东湛江,524003) |
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| 摘 要： | 目的 探讨厄贝沙坦对原发性高血压患者左心室肥厚(LVH)及心率变异性(HRV)的影响.方法 65例原发性高血压患者,每日清晨7 时口服厄贝沙坦,治疗前及治疗6个月后分别测定患者LVH及HRV.结果 治疗后的左室后壁舒张末期厚度(LVPWT)、左室舒张末期内径(LVDd)、室间隔舒张末期厚度( IVST)、左室重量指数(LVMI)均比治疗前明显减少(P<0.01);与治疗前相比,相邻正常RR 间期标准差 (SDNN)、相邻正常RR 间期差值的方差(RMSSD)、相邻正常RR 间期差值大于50 ms 的窦性心律占心搏总数的百分比(PNN50)、高频功率(HF)明显增加(P<0.01),而低频功率(LF)及LF/HF则明显降低(P<0.05或0.01).结论 厄贝沙坦对原发性高血压患者的LVH有显著的改善作用,对HRV有显著的扭转作用.
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| 关 键 词： | 厄贝沙坦 原发性高血压 左室肥厚 心率变异性 |
Effect of irbesartan on left ventricular hypertrophy and heart rate variability in patients with essential hypertension |
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| XU Jin-rong,XIN Zhu,ZENG Jian,ZHANG Lin.Effect of irbesartan on left ventricular hypertrophy and heart rate variability in patients with essential hypertension[J].Journal of Guangdong Medical College,2009,27(3):255-257. |
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| Authors: | XU Jin-rong XIN Zhu ZENG Jian ZHANG Lin |
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| Institution: | XU Jin-rong1,XIN Zhu1,ZENG Jian1,ZHANG Lin2 (1.Department of Internal Medicine,Second Affiliated Hospital of Guangdong Medical College,Zhanjiang 524003,China) |
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| Abstract: | Objective To study the effect of irbesartan on left ventricular hypertrophy(LVH)and heart rate variability(HRV)in patients with essential hypertension(EH).Methods Sixty-five EH patients received oral irbesartan once daily.LVH and HRV were determined before and 6 months after irbesartan treatment.Results Compared with before irbesartan treatment,standard deviation of normal to normal intervals(SDNN),rate mean square of the differences of successive RR intervals(RMSSD),percentage of RR intervals differing >50... |
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| Keywords: | irbesartan essential hypertension left ventricular hypertrophy heart rate variability |
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