PSMB7基因与阿尔茨海默病的相关性研究 |
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引用本文: | 钟望涛,赵斌,陈煜森,吴志红,山县英玖,三木哲郎.PSMB7基因与阿尔茨海默病的相关性研究[J].湛江医学院学报,2012,30(1):7-10. |
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作者姓名: | 钟望涛 赵斌 陈煜森 吴志红 山县英玖 三木哲郎 |
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作者单位: | 钟望涛 (广东医学院附属医院神经内科研究室,广东湛江,524001) ; 赵斌 (广东医学院附属医院神经内科研究室,广东湛江,524001) ; 陈煜森 (广东医学院附属医院神经内科研究室,广东湛江,524001) ; 吴志红 (重庆医科大学公共卫生学院流行病学教研室,重庆,400016) ; 山县英玖 (日本爱媛大学医学部老年医学讲座,日本爱嫒791-0295) ; 三木哲郎 (日本爱媛大学医学部老年医学讲座,日本爱嫒791-0295) ; |
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基金项目: | 广东医学院留学回国人员科研启动项目 |
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摘 要: | 目的探讨蛋白酶体亚基-B7(PSMB7)基因多态性、载脂蛋白E(ApoE)基因多态性和阿尔茨海默病(AD)的相关性。方法 376例日本AD患者(324例迟发型和52例早发型AD)和378例非痴呆对照组中,用TaqMan-PCR法检测PSMB7基因rs7871785(+561G/A)、rs3780199(+26651C/T)及APOE基因的单核苷酸多态性,并分析与AD的相关性。结果 PSMB7基因rs7871785 A/A纯合子频率在早发型AD中明显高于对照组(0.75 vs 0.60,P=0.037),而rs3780199 C/C纯合子频率在AD中明显高于对照组(0.23 vs 0.15,P=0.009)。在非APOE-ε4携带者中,AD患者rs3780199 C/C纯合子频率明显高于对照组(0.23 vs 0.16,P=0.005)。结论 PSMB7基因rs7871785多态位点A/A纯合子与早发型AD存在相关性,而rs3780199C/C纯合子独立于APOE-ε4基因与迟发型AD存在相关性。
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关 键 词: | 阿尔茨海默病 PSMB7基因 多态性 载脂蛋白E |
Association of PSMB7 gene polymorphisms with Alzheimer's disease |
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Institution: | ZHONG Wang-tao,ZHAO Bin,CHEN Yu-sen,WU Zhi-hong,Yamagata Hidehisa,Miki Tetsuro(1.Department of Neurology,Affiliated Hospital of Guangdong Medical College,Zhanjiang 524001,China) |
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Abstract: | Objective To study the association of proteasome subunit-beta type-7(PSMB7) and apolipoprotein E(APOE) gene polymorphisms with Alzheimer's disease(AD).Methods Single nucleotide polymorphisms(SNPs) of PSMB7 gene rs7871785(+561G/A) and rs3780199(+26651C/T)] and APOE gene were analyzed by TaqMan-PCR in 376 Japanese AD cases(including 324 late-onset AD and 52 early-onset AD) and 378 non-demented controls.Results The frequency of AA genotype of rs7871785 in early-onset AD and that of CC genotype of rs3780199 in AD were significantly higher compared with controls(0.75 vs 0.60,P=0.037;0.23 vs 0.15,P=0.009).Of the individuals without APOE-ε4 gene,only CC genotype of rs3780199 was associated with AD(0.23 vs 0.16,P=0.005).Conclusion AA genotype of rs7871785 is related to the early-onset AD,while CC genotype of rs3780199 is associated with late-onset AD independent of APOE-ε4 gene. |
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Keywords: | Alzheimer's disease PSMB7 gene polymorphism apolipoprotein E |
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