3．0T质子磁共振波谱在阿尔兹海默病的应用

目的观察3．0T氢质子磁共振波谱（IH—MRS）检测阿尔茨海默病（AD）的代谢变化及其临床意义。方法对30例临床确诊轻度AD组患者（AD组）和30名健康对照者（对照组）的1H—MRS进行分析，对两组颞叶海马区行1H—MRS检测，得到N-乙酰天门冬氨酸（N—acetyl aspartate，NAA）峰、肌酸（creatine，Cr）峰、胆碱（choline，Cho）．峰的积分值及计算出NAA／Cr、Cho／Cr和MI／Cr，并将两组数据进行对比。结果AD组患者颞叶海马区的NAA／Cr值为（1．47±0．15）、Cho／Cr值为（0．79±0．18）、MI／Cr值为（0．77±0．15），与对照组比较差异均有统计学意义（P〈0．01）。结论1H—MRS检测颞叶海马区的NAA／Cr比值降低及MI／Cr比值升高对轻度AD临床辅助诊断有一定提示价值。

Clinical application of 3.0T proton magnetic resonance spectroscopy in Alzheimer's disease

Objective To investigate the metabolic changes of patients with Alzheimer disease （AD） by 3.0T hydrogen proton magnetic re,＇~nance spectroscopy （IH-MRS）. Methods 1H-MRS was used to scan the hippocampus in 30 patients with mild AD and 30 normal controls, and the ratios of N-acetylaspartate （NAA）/creatine （Cr）, choline （Cho）/Cr, and myo-inositol （MI）/Cr were compared. Results The ratios of NAA/Cr, Cho/Cr and MI/Cr in AD patients were （ 1.47 ± 0.15）, （0.79 ± 0. 18） and （0.77± 0.15）, respectively. There were significant differences in these indexes between AD and control groups （P〈0. 01）. Conclusion The decrease of NAA/Cr ratio and increase of MI/Cr ratio in the hippocampus are helpful in the diagnosis of patients with mild AD.