脑梗死患者纤维蛋白原β-455G/A基因多态性的研究

目的探讨血浆纤维蛋白原（Fg）水平、β纤维蛋白原基因（Fgβ）-455 G/A多态性与脑梗死的关系。方法用PCR-RFLP（多聚酶链-限制性片段长度多态性）和比浊法分别检测220例脑梗死患者和140例健康体检者血浆Fgβ-455G/A基因多态性、Fg水平,并分析其与脑梗死的关系。结果脑梗死组的Fg水平（3.8±0.9）g/L]明显高于对照组（3.0±0.8）g/L]（P〈0.01）,脑梗死组A-455等位基因频率（30.2%）明显高于对照组（17.1%）（P〈0.01）。结论 Fg水平受Fgβ-455G/A基因多态性的影响,水平升高是脑梗死的危险因素。

β-fibrinogen gene-455G/A polymorphism in patients with cerebral infarction

Objective To study the relationship between plasma fibrinogen（Fg） level and β-fibrinogen（Fg β） gene-455A/G polymorphism and cerebral infarction（CI）.Methods Plasma Fg β gene-455A/G polymorphism and Fg level in 220 patients with cerebral infarction and 140 healthy controls were determined by PCR-RFLP and turbidimetry,respectively,and the relationship between them was analyzed.Results Plasma Fg level and Fg β-455 A allele frequency were significantly higher in CI group than those in control group （3.8±0.9）g/L vs（3.0±0.8）g/L,P〈0.01;30.2% vs 17.1%,P〈0.01].Conclusion Fg β gene-455A/G polymorphism can influence Fg content.Fg overexpression might be a risk factor for cerebral infarction.