慢性乙型肝炎患者血清胆碱酯酶水平与肝组织炎症关系的研究

目的：探讨慢性乙型肝炎患者血清胆碱脂酶（CHE）活性水平与肝组织炎症病理分级（G）的关系。方法：采用RI-1000TM全自动生化分析仪检测106例经病理证实的慢性乙型肝炎患者血清胆碱脂酶（CHE）．丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）活性水平．统计分析血清ALT、AST、CHE水平与肝组织病理炎症分级（G0～G4）的关系。结采：血清CHE水平随着肝组织炎症活动度增高而降低，而ALT、AST水平随着肝组织炎症活动度增高而升高；G4级患者的血清CHE水平明显低于G1、G2、G3级患者，G3级低于G1、G2级．差异有显著性（P〈0．05或0．01）。G4级患者的血清AST水平明显高于G1、G2、G3级患者．但G1、G2、G3级患者AST水平以及各炎症分级之间ALT水平差异无显著性（P〉0．05）。结论：CHE比ALT、AST更能反映肝损害的严重程度、是一项有意义的无创性指标。

Relationship between serum cholinesterase levels and liver inflammation grade in patients with chronic hepatitis B

Objective: To investigate the relationship between serum cholinesterase (CHE) level and liver inflammation grade (G) in patients with chronic hepatitis B. Methods: 106 patients of chronic hepatitis B diagnosed and graded histopathologically with the needle biopsy were enrolled in this study. The serum levels of CHE, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined with RI-1000TM autochemical analyzer. The relationship between the serum levels of CHE, ALT and AST and the inflammation grade of liver(G0G4)was statistically analyzed. Results: Following the exacerbation of hep atic inflammation , the CHE level decreased gradually, while the levels of AST and ALT increased gradually; the CHE level in G4 was obviously lower than in others (P<(0.01),) and the CHE level in G3 was lower than in G1 and G2 (P<0.05); AST level in G4 was obviously higher than in others (P<(0.01)),but there was no difference of AST level among G1, G2 and G3; No difference of ALT level was found among all grades of hepatitis(P>0.05). Conclusion: Serum CHE level could be a useful and harmless index because it could reflect the severity degree of hepatitis better than did serum ALT and AST levels.