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急性颅脑损伤患者外周血C-反应蛋白和IL-6水平的
引用本文:廖文焱,张美兰,王小梅,张良清,徐军发.急性颅脑损伤患者外周血C-反应蛋白和IL-6水平的[J].湛江医学院学报,2005,23(2):131-133.
作者姓名:廖文焱  张美兰  王小梅  张良清  徐军发
作者单位:廖文焱(广东省湛江市第二中医院,广东,湛江,524013);张美兰(广东省湛江市第二中医院,广东,湛江,524013);王小梅(广东医学院附属医院,广东,湛江,524001);张良清(广东医学院附属医院,广东,湛江,524001);徐军发(广东医学院临床免疫学教研室,广东,湛江,524023)
基金项目:湛江市科技攻关项目(No:ZK0123)
摘    要:目的检测急性颅脑损伤后患者外周血C-反应蛋白(CRP)和IL-6水平的动态变化,探讨其临床意义.方法选择77例不同病情的急性颅脑损伤患者作为研究对象,32例健康体检者作为对照组.采用免疫浊度法检测血浆CRP,ELISA法检测IL-6水平.结果急性颅脑损伤患者血浆CRP和IL-6水平均显著高于正常人对照组(P<0.01),且患者CRP和IL-6水平与病情呈正相关;各组患者在入院当天IL-6和CRP水平有所升高,并在入院1 d后继续升高,IL-6于3 d达最高水平,以后逐渐下降,CRP在1 d达高峰,随即开始下降;患者IL-6水平与CRP呈正相关(r=0.556,P<0.01).结论急性颅脑损伤患者外周血IL-6和CRP水平的变化与病情严重程度密切相关,IL-6在急性颅脑损伤中可能通过促进肝脏合成CRP,在一定程度上对神经系统起保护作用.

关 键 词:颅脑损伤  C-反应蛋白  白细胞介素-6
文章编号:1005-4057(2005)02-0131-03
修稿时间:2004年10月29

Dynamic changes of C-reactive protein and interleukin-6 in patients with acute traumatic brain injury
LIAO Wen-yan,ZHANG Mei-lan,WANG Xiao-mei,ZHANG Liang-qing,XU Jun-fa.Dynamic changes of C-reactive protein and interleukin-6 in patients with acute traumatic brain injury[J].Journal of Guangdong Medical College,2005,23(2):131-133.
Authors:LIAO Wen-yan  ZHANG Mei-lan  WANG Xiao-mei  ZHANG Liang-qing  XU Jun-fa
Abstract:Objective: To observe the dynamic changes of C-reactive protein (CRP) and interleukin-6 (IL-6) in patients with acute traumatic brain injury. Methods: Plasma levels of CRP and IL-6 were determined in 77 patients with acute traumatic brain injury and 32 healthy controls by immuno-nephelometry and ELISA, respectively. Results: CRP and IL-6 contents were significantly higher in brain injury group than those in control group (P<0.01), and correlated with the patient's condition. CRP and IL-6 concentrations increased on the admission day, and peaked on day 1 and 3, respectively. There was a positive correlation between them (r=0.556, P<0.01). Conclusion: CRP and IL-6 levels are related to the severity of patients with acute traumatic brain injury, and IL-6 may protect the nervous system from the damage via improving CRP synthesis in liver.
Keywords:traumatic brain injury  C-reactive protein  interleukin-6
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