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Pharmacokinetics of Flunixin Meglumine After Intravenous and Intramuscular Administration in Pigs
作者姓名:YU  Zu-gong  JIANG  Chun-mao  GUO  Yong-gang  HU  Yi-yi  CHEN  Da-jian
作者单位:[1]College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, P.R.China [2]Jiangsu Animal Husbandry and Veterinary College, Taizhou 225300, P.R.China
摘    要:Pharmacokinetics of flunixin meglumine (FM) was investigated in 14 healthy pigs following single intravenous (i.v.) and intramuscular (i.m.) administration of the drug at the dosage of 2.2 and 1.1 mg kg-1. Blood samples were collected at different intervals after administration, and concentrations of FM were determined by HPLC method with a limit of detection of 0.1μg mL-1. The FM concentration-time data were fitted to a two-compartment open model after single i.v. dosing in pigs. The main pharmacokinetic parameters were as follows: tl/2a, 0.49 ± 0.03 and 0.58±0.07 h; tl/2β, 6.28±0.13 and 7.37 ±0.59 h; V/F, 0.01 ±0.001 and 0.01 ±0.002 L kg-1; CL, 0.01 ± 0.002 and 0.01 ± 0.002 L h-l; AUC, 237.73 ± 52.46 and 147.71 ± 36.76μg h-1 mL-1. The drug concentration-time data were fitted to a two-compartment model with first-order absorption after single i.m. administration in pigs. The main pharmacokinetic parameters were as follows: t1/2α, 0.90± 0.07 and 0.86±0.10 h; t1/2β, 8.79±0.85 and 9.60±0.10 h; V/F, 0.02±0.004 and 0.02±0.003 L kg-1; CL, 0.01±0.002 and 0.01 ±0.003 L h-l; AUC, 174.63 ± 45.84 and 112.42 ± 31.19 pg h-1 mL 1. The results of the present study showed that FM was rapidly absorbed, extensively distributed, and slowly eliminated in pigs. The drug was completely absorbed after single i.m. administration and a good bioavailability in pigs.

关 键 词:  甲葡胺  药物代谢动力学  高压液相色谱法

Pharmacokinetics of Flunixin Meglumine After Intravenous and Intramuscular Administration in Pigs
YU Zu-gong JIANG Chun-mao GUO Yong-gang HU Yi-yi CHEN Da-jian.Pharmacokinetics of Flunixin Meglumine After Intravenous and Intramuscular Administration in Pigs[J].Agricultural Sciences in China,2007,6(11):1396-1401.
Authors:YU Zu-gong  JIANG Chun-mao  GUO Yong-gang  HU Yi-yi  CHEN Da-jian
Institution:1. Clinic for Equine Surgery, Equine Department, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland;2. Clinic for Equine Internal Medicine, Equine Department, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland;3. Anaesthesiology Section, Equine Department, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 258c, 8057 Zurich, Switzerland;1. Formulation & Product Development Lead, Process & Product Development, Radient Technologies Inc., Edmonton, AB, Canada;2. Biolink Consultancy, New Denver, BC, Canada
Abstract:Pharmacokinetics of flunixin meglumine (FM) was investigated in 14 healthy pigs following single intravenous (i.v.) and intramuscular (i.m.) administration of the drug at the dosage of 2.2 and 1.1 mg kg-1. Blood samples were collected at different intervals after administration, and concentrations of FM were determined by HPLC method with a limit of detection of 0.1 μg mL-1. The FM concentration-time data were fitted to a two-compartment open model after single i.v.dosing in pigs. The main pharmacokinetic parameters were as follows: t1/2α, 0.49 ±0.03 and 0.58 ±0.07 h; t1.2β, 6.28±0.13 and 7.37 ±0.59 h; V/F, 0.01 ±0.001 and 0.01±0.002 L kg-1; CL, 0.01 ±0.002 and 0.01±0.002 L h-1; AUC, 237.73 ±52.46 and 147.71±36.76 μg h-1 mL-1. The drug concentration-time data were fitted to a two-compartment model with first-order absorption after single i.m. administration in pigs. The main pharmacokinetic parameters were as follows: t1/2α, 0.90±0.07 and 0.86±0.10 h;t1/2β, 8.79±0.85 and 9.60±0.10 h; V/F, 0.02±0.004 and 0.02±0.003 L kg-1; CL, 0.01±0.002 and 0.01 ±0.003 L h-1; AUC, 174.63± 45.84 and 112.42 ±31.19 μg h-1 mL-1. The results of the present study showed that FM was rapidly absorbed, extensively distributed, and slowly eliminated in pigs. The drug was completely absorbed after single i.m. administration and a good bioavailability in pigs.
Keywords:flunixin meglumine (FM)  pharmacokinetics  pigs  HPLC
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