Strategies for enhancing DNA vaccine potency by targeting antigen-presenting cells |
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| Authors: | Xingxing Wang Xiujin Li Fei Zhong Nan Li Dongmei Han Sumin Pan |
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| Institution: | 1.Department of Basic Veterinary Medicine, College of Animal Science and Technology,Agricultural University of Hebei,Baoding,China;2.Department of Biotechnology, College of Environmental and Chemical Engineering,Yanshan University,Qinhuangdao,China |
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| Abstract: | The potency of DNA vaccines to stimulate the immune response, especially the T-cell immune response against viral infections and tumors, depends mainly on the ability of antigen-presenting cells to process and present DNA-encoded antigens. Targeting the specific antigen to antigen-presenting cells is believed to be a crucial step for eliciting the T-cell response. Many strategies for enhancing DNA vaccine potency by targeting antigen-presenting cells have been developed. In this article, we generally introduce a T cell immune system and review some strategies which have been recently developed for enhancing DNA vaccine potency. |
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